Skin is an attractive site for drug administration partly because of its easy accessibility and favorable properties (e.g., less invasiveness and high patient compliance) over some other common routes of administration. Despite this, the efficiency in transdermal drug delivery has been largely limited by poor skin permeation. To address this problem, this study reports the generation of oleic acid-containing vesicles, which can enhance the drug delivery efficiency while showing good stability and limited skin disruption. Upon being loaded into a complex gel, along with the incorporation of the polymer blending technique, a delivery system exhibiting tunable transdermal flux of 2,3,5,4′-tetrahydroxystilbene 2-O-β-D-glucoside is reported. Taking the good biocompatibility and tunable delivery performance into account, our system warrants further development and optimization for future applications in the treatment of skin diseases.

中文翻译：

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离子交联的复合凝胶载有含油酸的囊泡，用于透皮给药。

皮肤是药物给药的一个吸引人的部位，部分原因是与其他一些常见给药途径相比，皮肤易于接近且具有良好的特性（例如，侵入性较小和患者依从性较高）。尽管如此，由于不良的皮肤渗透而大大限制了透皮药物递送的效率。为了解决这个问题，本研究报告了含油酸囊泡的产生，该囊泡可提高药物递送效率，同时显示出良好的稳定性和有限的皮肤破坏能力。据报道，在加载到复杂的凝胶中后，随着聚合物共混技术的加入，递送系统表现出可调的2,3,5,4'-四羟基hydroxy2-O-β-D-葡萄糖苷透皮通量。考虑到良好的生物相容性和可调的输送性能，