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Pharmacokinetic comparison of six anthelmintics in sheep, goats, and cattle.
Journal of Veterinary Pharmacology and Therapeutics ( IF 1.3 ) Pub Date : 2020-08-01 , DOI: 10.1111/jvp.12897
Michael J Myers 1 , Karyn D Howard 1 , Joseph C Kawalek 1
Affiliation  

This study was initiated to determine whether a comparative pharmacokinetic (PK) approach could be used to expand the pool of approved anthelmintics for minor ruminant species. Accordingly, the PK profiles of six anthelmintics (levamisole, albendazole, fenbendazole, moxidectin, doramectin, and ivermectin) in sheep, goats, and cattle were determined. The PK values determined for each anthelmintic included Tmax, Tlast, Cmax, AUC, AUC/dose, and Cmax/dose. The results of this study demonstrate that a comparative PK approach does not show commonality in the way these six anthelmintics are individually processed by these three ruminants. While some drugs demonstrated identical PK profiles between sheep and goats, none of these drugs demonstrated PK profiles in sheep and goats comparable to the PK profiles found in cattle. The results from this study suggest drug approval across these three ruminants is not a viable concept. However, the resulting PK profiles for each combination of drug and ruminant species represents a new dataset that can be used to support the US FDA Center for Veterinary Medicine's Minor Use/Minor Species indexing process for drug approvals in minor species such as sheep and goats.

中文翻译:

六种驱虫药在绵羊、山羊和牛体内的药代动力学比较。

本研究旨在确定是否可以使用比较药代动力学 (PK) 方法来扩大已批准用于小型反刍动物的驱虫药库。因此,确定了六种驱虫药(左旋咪唑、阿苯达唑、芬苯达唑、莫昔克丁、多拉菌素和伊维菌素)在绵羊、山羊和牛中的 PK 谱。为每种驱虫药确定的 PK 值包括T maxT lastC max、AUC、AUC/剂量和C max/剂量。该研究的结果表明,比较 PK 方法在这三种反刍动物单独处理这六种驱虫药的方式上没有表现出共性。虽然一些药物在绵羊和山羊之间表现出相同的 PK 特征,但这些药物在绵羊和山羊中的 PK 特征都没有与在牛中发现的 PK 特征相媲美。这项研究的结果表明,这三种反刍动物的药物批准并不是一个可行的概念。然而,药物和反刍动物物种的每种组合的最终 PK 概况代表了一个新的数据集,可用于支持美国 FDA 兽医中心的次要用途/次要物种索引过程,用于在诸如绵羊和山羊等次要物种中进行药物批准。
更新日期:2020-08-01
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