Cold‐inducible RNA‐binding protein (CIRP) was previously identified as an intracellular stress‐response protein, which can respond to a variety of stress conditions by changing its expression and regulating mRNA stability through its binding site on the 3′‐UTR of its targeted mRNAs. Recently, extracellular CIRP (eCIRP) was discovered to be present in various inflammatory conditions and could act as a pro‐inflammatory factor. Genetic studies have demonstrated a key role for eCIRP in inflammatory conditions that led to the importance of targeting eCIRP in these diseases. Currently, the underlying mechanism of eCIRP‐induced inflammation is under intensive investigation and several signalling pathways are being explored. Here, we epitomized various signalling pathways that mediate the pro‐inflammatory effects of CIRP and also recapitulated all the CIRP‐derived peptides that can block the interaction between CIRP and its receptors in inflammatory setting.

中文翻译：

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炎性疾病中的冷诱导RNA结合蛋白（CIRP）：其相关信号通路的分子见解。

冷诱导RNA结合蛋白（CIRP）先前被鉴定为细胞内应激反应蛋白，它可以通过改变其表达并通过其3'-UTR上的结合位点调节mRNA稳定性来应对多种应激条件靶向的mRNA。最近，发现细胞外CIRP（eCIRP）存在于各种炎症条件下，并且可以作为促炎因子。遗传学研究表明，eCIRP在炎症中起着关键作用，导致在这些疾病中靶向eCIRP的重要性。目前，eCIRP诱导炎症的潜在机制正在深入研究中，并且正在探索几种信号传导途径。这里，