Owing to a high‐volume industrial usage of the halogens chlorine (Cl2) and bromine (Br2), they are stored and transported in abundance, creating a risk for accidental or malicious release to human populations. Despite extensive efforts to understand the mechanisms of toxicity upon halogen exposure and to develop specific treatments that could be used to treat exposed individuals or large populations, until recently, there has been little to no effort to determine whether there are specific features and or the mechanisms of halogen exposure injury in newborns or children. We established a model of neonatal halogen exposure and published our initial findings. In this review, we aim to contrast and compare the findings in neonatal mice exposed to Br2 with the findings published on adult mice exposed to Br2 and the neonatal murine models of bronchopulmonary dysplasia. Despite remarkable similarities across these models in overall alveolar architecture, there are distinct functional and apparent mechanistic differences that are characteristic of each model. Understanding the mechanistic and functional features that are characteristic of the injury process in neonatal mice exposed to halogens will allow us to develop countermeasures that are appropriate for, and effective in, this unique population.

中文翻译：

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发育中肺的卤素暴露损伤

由于卤素氯 (Cl2) 和溴 (Br2) 的大量工业使用，它们被大量储存和运输，给人类带来意外或恶意释放的风险。尽管在了解卤素暴露后的毒性机制和开发可用于治疗暴露的个体或大量人群的特定治疗方法方面付出了广泛的努力，但直到最近，几乎没有努力确定是否存在特定的特征和/或机制新生儿或儿童的卤素暴露损伤。我们建立了新生儿卤素暴露模型并发表了我们的初步发现。在本次审查中，我们旨在对比和比较暴露于 Br2 的新生小鼠的发现与暴露于 Br2 的成年小鼠和支气管肺发育不良的新生鼠模型的发现。尽管这些模型在整体肺泡结构上有显着的相似性，但每个模型都有明显的功能差异和明显的机械差异。了解暴露于卤素的新生小鼠损伤过程的机制和功能特征将使我们能够开发出适合这一独特人群的有效对策。