Research question

The question of interest for this study was to examine the chance of a live birth following assisted reproductive technology (ART) treatment in women with epilepsy compared with women without epilepsy. In sub-analyses, the chance of biochemical and clinical pregnancies, and the impact of antiepileptic drugs (AED) treatment prior to embryo transfer, was analysed.

Design

This register-based cohort study was based on the Danish ART register comprising all women who underwent embryo transfer during 2006 to 2017, which included 730 ART treatments in 264 women with a history of epilepsy, and 128,387 ART treatments in 42,938 women without epilepsy. Adjustments were made for comorbidity, women's age, calendar year, type of infertility treatment and cause of infertility. A possible impact of AED use at the time of embryo transfer was studied in a sub-analysis. The primary outcome was live birth within a period of 140–308 days after the date of embryo transfer.

Results

The adjusted odds ratio for a live birth per embryo transfer in women with epilepsy, relative to women without epilepsy, was 1.06 (95% confidence interval [CI] 0.88–1.28). The adjusted odds ratio for a live birth among users of an AED was 1.22 (95% CI 0.77–1.92) relative to women who had stopped the use of AED prior to embryo transfer.

Conclusions

The chances of a live birth per embryo transfer were similar in women with and without epilepsy. These are novel and reassuring findings on the efficacy of infertility treatment in women with epilepsy.

中文翻译：

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辅助生殖治疗对癫痫女性的疗效。

研究问题

本研究感兴趣的问题是检查与非癫痫妇女相比，癫痫妇女在辅助生殖技术 (ART) 治疗后活产的机会。在子分析中，分析了生化和临床妊娠的机会，以及胚胎移植前抗癫痫药物 (AED) 治疗的影响。

设计

这项基于登记册的队列研究基于丹麦 ART 登记册，包括 2006 年至 2017 年期间接受胚胎移植的所有女性，其中包括对 264 名有癫痫病史的女性进行了 730 次 ART 治疗，以及对 42,938 名没有癫痫病史的女性进行了 128,387 次 ART 治疗。对合并症、女性年龄、日历年、不孕症治疗类型和不孕症原因进行了调整。在子分析中研究了在胚胎移植时使用 AED 的可能影响。主要结果是胚胎移植日期后 140-308 天内的活产。

结果

与没有癫痫的女性相比，癫痫女性每次胚胎移植活产的调整比值比为 1.06（95% 置信区间 [CI] 0.88-1.28）。相对于在胚胎移植前停止使用 AED 的女性，AED 使用者活产的调整优势比为 1.22（95% CI 0.77–1.92）。

结论

每次胚胎移植活产的机会在患有和不患有癫痫症的女性中是相似的。这些是关于不孕不育治疗对癫痫女性的疗效的新颖且令人放心的发现。