Abstract Pb accumulates in bone over long periods of time, and the isotopic effects of this accumulation are poorly studied. The use of Pb isotopes in bones as a metric of exposure requires additional constraints on the relationship between the isotopic composition of the exposure source and resulting isotopic composition of the bone. Here, we present a Pb isotope study of two cows that were associated with the blood Pb proficiency testing program at the University of Wisconsin-Madison State Laboratory of Hygiene (WSLH). These two cows were born and raised under the same conditions on the same farm, but were subjected to different levels of Pb exposure during that time period. Pb isotopes were measured in femur bones subsampled from each cow and the Pb isotopic composition of the exposure source (Pb nitrate) used for dosing the animals was also measured. Pb isotopic compositions of nearby (

中文翻译：

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已知暴露源对摄入铅奶牛骨骼中铅同位素的影响

摘要 Pb 长期在骨骼中积累，而这种积累的同位素效应研究甚少。使用骨骼中的 Pb 同位素作为暴露量度，需要对暴露源的同位素组成与产生的骨骼同位素组成之间的关系进行额外的限制。在这里，我们介绍了与威斯康星大学麦迪逊分校卫生实验室 (WSLH) 的血液 Pb 能力测试计划相关的两头奶牛的 Pb 同位素研究。这两只奶牛在同一农场的相同条件下出生和饲养，但在此期间受到不同水平的铅暴露。在从每头奶牛取样的股骨骨中测量了铅同位素，并且还测量了用于给动物给药的暴露源（硝酸铅）的铅同位素组成。附近的铅同位素组成（