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Optimization and application of hollow fiber liquid-phase microextraction and microwave-assisted extraction for the analysis of non-steroidal anti-inflammatory drugs in aqueous and plant samples.
Environmental Monitoring and Assessment ( IF 3 ) Pub Date : 2020-08-01 , DOI: 10.1007/s10661-020-08527-4
Nomchenge Yamkelani Mlunguza 1 , Somandla Ncube 2 , Precious Nokwethemba Mahlambi 3 , Luke Chimuka 4 , Lawrence Mzukisi Madikizela 1
Affiliation  

Human consumption of non-steroidal anti-inflammatory drugs (NSAIDs) is increasing, which poses a great risk of pollution by these pharmaceuticals on the aquatic environment. Therefore, this study reports the optimization of microwave-assisted extraction using water as a green solvent and hollow fiber liquid-phase microextraction (HF-LPME) methods followed by high-performance liquid chromatography-high resolution mass spectrometry analysis of NSAIDs in wastewater and aquatic plant, Eichhornia crassipes. The optimized MAE resulted in efficient transfer of selected NSAIDs from plant samples into the aqueous phase yielding the recoveries ranging from 91 to115%. A multivariate approach based on half fractional factorial and central composite design was used during the optimization of HF-LPME. Under the optimized conditions, the maximum enrichment factors for naproxen, fenoprofen, diclofenac, and ibuprofen were 49, 126, 93 and 156, respectively. The overall analytical method recoveries ranged from 86 to 116% while the limits of quantitation for wastewater and plant samples ranged from 0.09 to 0.59 μg L−1 and from 0.11 to 0.59 μg kg−1, respectively. The precision of the proposed analytical method which was measured in terms of RSD values did not exceed 5%. Naproxen was the most abundant compound in both wastewater and the Eichhornia crassipes plant samples with concentrations of up to 3.30 μg L−1 and 10.97 μg kg−1, respectively. The detection of NSAIDs in Eichhornia crassipes means this plant has the ability to bioaccumulate pharmaceutical load in surface water.

中文翻译:

中空纤维液相微萃取和微波辅助萃取用于水和植物样品中非甾体类抗炎药分析的优化和应用。

人类对非甾体类抗炎药(NSAIDs)的消费正在增加,这给这些药物在水生环境中造成污染带来了极大的风险。因此,本研究报告以水为绿色溶剂和中空纤维液相微萃取(HF-LPME)方法进行微波辅助萃取,然后进行高效液相色谱-高分辨率质谱分析废水和水体中的NSAID,从而进行了优化。植物,凤眼莲。优化的MAE可将选定的NSAID从植物样品有效转移到水相中,回收率在91%到115%之间。在HF-LPME的优化过程中,采用了基于半分数阶乘和中心复合设计的多元方法。在优化的条件下,萘普生,非诺洛芬,双氯芬酸和布洛芬的最大富集因子分别为49、126、93和156。总体分析方法的回收率为86%至116%,而废水和植物样品的定量限为0.09至0.59μgL -1和0.11至0.59μgkg -1, 分别。根据RSD值测量的拟议分析方法的精度不超过5%。萘普生是废水和凤眼凤梨植物样品中最丰富的化合物,浓度分别高达3.30μgL -1和10.97μgkg -1。在凤眼莲中检测到NSAIDs意味着该植物具有生物积聚地表水中药物负荷的能力。
更新日期:2020-08-01
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