OBJECTIVE:This study aims to analyze and compare the diagnostic effectiveness of 320-row multi-detector computed tomography for coronary artery angiography (MDCTA) in subjects with and without sublingual vasodilator (nitroglycerin). MATERIALS AND METHODS:From September 2015 to September 2016, 70 individuals without history of major cardiovascular diseases who underwent MDCTA for health examination were retrospectively categorized into sublingual nitroglycerin (NTG) and non-NTG groups. Medical history, CT dose index (CTDI), and multi-slice CT images were compared between two groups. A diameter of coronary artery (DA, mm) was computed and analyzed. RESULTS:A total of 41 males and 29 females (mean age: 55.43±8.84 years, range: 34– 76) were reviewed. Normal and abnormal MDCTA findings were noted in 54 and 16 participants, respectively, with the detection rate of coronary artery disease being 23%. There was no significant difference in inter-observer variability of coronary CTA image quality and diagnosis between the NTG and non-NTG groups among three experienced radiologists. Although the percentage dilatation of left anterior descending branch (LAD), right coronary artery (RCA) and left circumflex branch (LCX) following in the NTG group were 12.4%, 12.8% and 25.3%, respectively (p < 0.01), there was no significant difference in image quality and diagnosis between the two groups. CONCLUSIONS:Despite the recommendation of routine nitroglycerin use for subjects undergoing computed tomography for coronary artery angiography, our results showed no significant advantage of its use in improving image quality and rate of diagnosis accuracy.

中文翻译：

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使用 320 排多探测器计算机断层扫描诊断冠状动脉检查时，硝酸甘油的必要性值得怀疑。

目的：本研究旨在分析和比较 320 排多排计算机断层扫描对冠状动脉血管造影 (MDCTA) 的诊断效果，对使用和不使用舌下血管扩张剂（硝酸甘油）的受试者进行诊断。材料与方法：2015年9月至2016年9月，将70例无重大心血管疾病病史行MDCTA健康检查的个体回顾性分为舌下含服硝酸甘油（NTG）组和非NTG组。比较两组病史、CT剂量指数（CTDI）和多层CT图像。计算并分析冠状动脉的直径（DA，mm）。结果：总共审查了 41 名男性和 29 名女性（平均年龄：55.43±8.84 岁，范围：34-76）。分别在 54 和 16 名参与者中发现了正常和异常的 MDCTA 结果，冠心病检出率为23%。在三位经验丰富的放射科医生中，NTG 组和非 NTG 组之间冠状动脉 CTA 图像质量和诊断的观察者间变异性没有显着差异。虽然 NTG 组的左前降支 (LAD)、右冠状动脉 (RCA) 和左回旋支 (LCX) 的扩张百分比分别为 12.4%、12.8% 和 25.3%（p < 0.01），但两组在图像质量和诊断上无显着差异。结论：尽管建议对接受冠状动脉血管造影的计算机断层扫描的受试者常规使用硝酸甘油，但我们的结果显示其在提高图像质量和诊断准确率方面没有显着优势。