More than 250 years ago, William Hunter stated that when cartilage is destroyed it never recovers. In the last 20 years, the understanding of the mechanisms that lead to joint formation and the knowledge that some of these mechanisms are reactivated in the homeostatic responses of cartilage to injury has offered an unprecedented therapeutic opportunity to achieve cartilage regeneration. Very large investments in ambitious clinical trials are finally revealing that, although we do not have perfect medicines yet, disease modification is a feasible possibility for human osteoarthritis.

中文翻译：

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临床软骨修复联合开发的经验教训

250 多年前，威廉·亨特 (William Hunter) 表示，当软骨被破坏时，它永远不会恢复。在过去的 20 年中，对导致关节形成的机制的了解以及其中一些机制在软骨对损伤的稳态反应中被重新激活的知识为实现软骨再生提供了前所未有的治疗机会。对雄心勃勃的临床试验的巨额投资最终表明，尽管我们还没有完美的药物，但改变疾病对于人类骨关节炎来说是一种可行的可能性。