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Evaluating the influences of major depression and posttraumatic stress disorder on trauma and alcohol cue reactivity.
Addictive Behaviors ( IF 4.4 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.addbeh.2020.106596
Hanaan Bing-Canar 1 , Alexander Demos 1 , Robin J Mermelstein 1 , Erin C Berenz 1
Affiliation  

Despite support for the role of self-medication alcohol use in the etiology and maintenance of comorbid posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD), theoretical and empirical models of PTSD-AUD rarely account for the role of common comorbidities in risk processes, such as major depressive disorder (MDD). The current study examined the main and interactive effects of PTSD and depressive symptoms on patterns of trauma and alcohol cue reactivity to elucidate potential influences of depression on conditioned craving responses to trauma memories. It was hypothesized that depressive symptoms would be associated with greater cue reactivity (i.e., craving and salivation) to personalized trauma cues, above and beyond the influence of PTSD symptoms. Participants were 184 trauma-exposed young adults (50% female) endorsing current weekly alcohol use. Patterns of craving and salivation were assessed in response to four combinations of narrative (trauma vs. neutral) and beverage (alcohol vs. water) cues. Forward-fitted linear mixed effects models with deviance testing were conducted to ascertain the impact of the within-subjects factors (narrative and beverage cues) and covariates (PTSD and depressive symptoms) on self-reported and physiological (salivation) alcohol craving. Depressive symptoms were associated with elevated drinking coping motives, AUD symptom severity, and alcohol use problems at baseline; however, depressive symptoms did not show main or interactive effects with narrative or beverage cues to predict craving or salivation, p’s > 0.05. Results suggest that, in the context of PTSD symptoms, depressive symptoms may not exacerbate alcohol craving responses to trauma reminders or alcohol cues.



中文翻译:

评估重度抑郁症和创伤后应激障碍对创伤和酒精提示反应的影响。

尽管支持自我用药酒精使用在共病创伤后应激障碍 (PTSD) 和酒精使用障碍 (AUD) 的病因和维持中的作用,但 PTSD-AUD 的理论和经验模型很少解释常见合并症在风险中的作用过程,例如重度抑郁症 (MDD)。目前的研究检查了创伤后应激障碍和抑郁症状对创伤模式和酒精提示反应的主要和交互影响,以阐明抑郁对创伤记忆条件渴望反应的潜在影响。据推测,抑郁症状与个体化创伤线索的更大线索反应(即渴望和流口水)有关,超出了创伤后应激障碍症状的影响。参与者是 184 名受过创伤的年轻人(50% 为女性),他们支持当前每周饮酒。根据叙事(创伤与中性)和饮料(酒精与水)线索的四种组合,评估渴望和流涎的模式。进行了带有偏差测试的前向拟合线性混合效应模型,以确定受试者内部因素(叙述和饮料线索)和协变量(PTSD 和抑郁症状)对自我报告和生理(流涎)酒精渴望的影响。抑郁症状与饮酒应对动机、澳元症状严重程度和基线饮酒问题有关;然而,抑郁症状并没有显示出与叙事或饮料线索的主要或交互作用来预测渴望或流口水,根据叙事(创伤与中性)和饮料(酒精与水)线索的四种组合,评估渴望和流涎的模式。进行了带有偏差测试的前向拟合线性混合效应模型,以确定受试者内部因素(叙述和饮料线索)和协变量(PTSD 和抑郁症状)对自我报告和生理(流涎)酒精渴望的影响。抑郁症状与饮酒应对动机、澳元症状严重程度和基线饮酒问题有关;然而,抑郁症状并没有显示出与叙事或饮料线索的主要或交互作用来预测渴望或流口水,根据叙事(创伤与中性)和饮料(酒精与水)线索的四种组合,评估渴望和流涎的模式。进行了带有偏差测试的前向拟合线性混合效应模型,以确定受试者内部因素(叙述和饮料线索)和协变量(PTSD 和抑郁症状)对自我报告和生理(流涎)酒精渴望的影响。抑郁症状与饮酒应对动机、澳元症状严重程度和基线饮酒问题有关;然而,抑郁症状并没有显示出与叙事或饮料线索的主要或交互作用来预测渴望或流口水,进行了带有偏差测试的前向拟合线性混合效应模型,以确定受试者内部因素(叙述和饮料线索)和协变量(PTSD 和抑郁症状)对自我报告和生理(流涎)酒精渴望的影响。抑郁症状与饮酒应对动机、澳元症状严重程度和基线饮酒问题有关;然而,抑郁症状并没有显示出与叙事或饮料线索的主要或交互作用来预测渴望或流口水,进行了带有偏差测试的前向拟合线性混合效应模型,以确定受试者内部因素(叙述和饮料线索)和协变量(PTSD 和抑郁症状)对自我报告和生理(流涎)酒精渴望的影响。抑郁症状与饮酒应对动机、澳元症状严重程度和基线饮酒问题有关;然而,抑郁症状并没有显示出与叙事或饮料线索的主要或交互作用来预测渴望或流口水,AUD 症状严重程度和基线时的酒精使用问题;然而,抑郁症状并没有显示出与叙事或饮料线索的主要或交互作用来预测渴望或流口水,AUD 症状严重程度和基线时的酒精使用问题;然而,抑郁症状并没有显示出与叙事或饮料线索的主要或交互作用来预测渴望或流口水,p > 0.05。结果表明,在 PTSD 症状的背景下,抑郁症状可能不会加剧对创伤提示或酒精提示的酒精渴望反应。

更新日期:2020-08-09
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