Homonymous hemimacular thinning of the retinal ganglion cell-inner plexiform layer (GCIPL) on optical coherence tomography (OCT) in the absence of significant visual field defects may be identified in the workup of patients with visual complaints, but the causes of this finding remain unknown. We retrospectively reviewed 1425 consecutive patients referred for neuro-ophthalmic assessment who had high quality OCT scans and reliable Humphrey 24-2 SITA-Fast testing. A total of 7 patients, 3 females and 4 males, with a mean age of 39.4 ± 10.5 years that had homonymous thinning of the OCT macular-GCIPL without significant visual field defects were included in the study. Four patients had demyelinating disease and 3 patients had traumatic brain injury. Three patients with demyelinating disease had a documented prior homonymous visual field defect that resolved. The differential diagnosis of homonymous hemimacular thinning of the GCIPL without obvious visual field defects includes previous retrochiasmal demyelination and traumatic brain injury. OCT GCIPL provides a permanent objective way of documenting previous retrochiasmal disease including demyelination and may be helpful in establishing dissemination in time and space in patients being evaluated for multiple sclerosis.

中文翻译：

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具有保留视觉功能的神经节细胞内丛状层同名半黄斑萎缩

在没有明显视野缺损的情况下，光学相干断层扫描 (OCT) 上视网膜神经节细胞内丛状层 (GCIPL) 的同名半黄斑变薄可以在有视力问题的患者的检查中发现，但这一发现的原因仍然未知. 我们回顾性审查了 1425 名连续接受神经眼科评估的患者，这些患者具有高质量的 OCT 扫描和可靠的 Humphrey 24-2 SITA-Fast 测试。共有 7 名患者，3 名女性和 4 名男性，平均年龄为 39.4 ± 10.5 岁，OCT 黄斑-GCIPL 同向变薄，无明显视野缺损。4 名患者患有脱髓鞘疾病，3 名患者患有外伤性脑损伤。三名患有脱髓鞘疾病的患者先前记录的同名视野缺损已解决。无明显视野缺损的 GCIPL 同向半黄斑变薄的鉴别诊断包括既往视交叉后脱髓鞘和外伤性脑损伤。OCT GCIPL 提供了一种永久客观的方式来记录以前的视交叉后疾病，包括脱髓鞘，并且可能有助于在接受多发性硬化症评估的患者中建立时间和空间的传播。