BACKGROUND Nervous system is affected in 25% of patients with sarcoidosis. Current literature is largely limited to case reports with disproportionate Caucasian population. We aim to evaluate differences in presentation, management and outcomes by race in neurosarcoidosis. METHODS Clinical and demographic data on consecutive patients fulfilling Zajicek criteria for neurosarcoidosis from 1995 to 2016 at Henry Ford Hospital were extracted. Disparities in clinical presentation, laboratory values, radiological features, treatment and outcomes, were compared between two groups: African Americans (AA) and non-AA using chi-squared tests, two sample t-test for age and Wilcoxon two sample tests. RESULTS A total of 118 patients were included, of which 58% were female and 73% were AA. The diagnosis of neurosarcoidosis was noted to be definite (25%), probable (64%) and possible (11%). AA patients had a significantly higher rate of elevated erythrocyte sedimentation rate (62% vs 24%, P = .005) and had lower resolution of abnormalities on follow-up imaging (14% vs 41%, P = .017). There was no difference in disability on follow-up (25% vs 33%, P = .43) or mortality (13% vs 9%, P = .6). CONCLUSIONS There were no differences in presentation, management and outcomes by race. Discordance in the clinical and radiological data by race has clinical implications and needs further investigation.

中文翻译：

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种族对神经结节病临床表现和结果的影响

背景 25% 的结节病患者神经系统受到影响。目前的文献主要限于具有不成比例的高加索人口的病例报告。我们的目标是评估神经结节病在表现、管理和结果方面的差异。方法 提取 1995 年至 2016 年在亨利福特医院符合 Zajicek 神经结节病标准的连续患者的临床和人口统计学数据。比较两组在临床表现、实验室值、放射学特征、治疗和结果方面的差异：非裔美国人 (AA) 和非 AA 使用卡方检验、年龄的两个样本 t 检验和 Wilcoxon 的两个样本测试。结果共纳入118例患者，其中58%为女性，73%为AA。神经结节病的诊断是明确的（25%），可能 (64%) 和可能 (11%)。AA 患者的红细胞沉降率升高率显着更高（62% 对 24%，P = .005），并且随访影像学异常的分辨率较低（14% 对 41%，P = .017）。随访期间的残疾（25% 对 33%，P = .43）或死亡率（13% 对 9%，P = .6）没有差异。结论 种族在表现、管理和结果方面没有差异。不同种族的临床和放射学数据不一致具有临床意义，需要进一步调查。43) 或死亡率（13% 对 9%，P = .6）。结论 种族在表现、管理和结果方面没有差异。不同种族的临床和放射学数据不一致具有临床意义，需要进一步调查。43) 或死亡率（13% 对 9%，P = .6）。结论 种族在表现、管理和结果方面没有差异。不同种族的临床和放射学数据不一致具有临床意义，需要进一步调查。