Introduction

The incidence of lung cancer and acute ischemic stroke remains high in recent years, both of which occur mostly in people over 60 years old. In the present study, we aimed to further clarify the pathogenesis of lung cancer-associated acute ischemic stroke (LCA-AIS) by comparing and analyzing clinical characteristics of stroke patients with or without lung cancer.

Methods

A total of 51 patients with lung cancer were selected as the case group (LCSG), and 78 patients without cancer history were adopted as the control group (SG). The data collected in this study included sex, age, traditional cerebrovascular disease risk factors (TCDRFs), blood test index, imaging findings, etiological typing, and prognosis evaluation. SPSS21.0 software was used for statistical analysis. Normally distributed data were analyzed by t-test, and count data were analyzed by chi-square test or exact probability method. P < 0.05 was considered statistically significant.

Results

In the case group, the levels of plasma D-dimer, fibrinogen degradation products (FDPs) and NIHSS, as well as the mRS score and mortality of patients, were higher, while the levels of RBC, Hb and Hcy were lower compared with the control group. Imaging findings showed that multivessel involvement was more common in the case group, and the infarcts were more likely to be multiple and involved in both the anterior and posterior circulations. The TOAST classification of LCSG was dominated by stroke of undetermined etiology (SUE) and stroke of other determined etiology (SOE). Statistical analysis showed that the patients were more likely to suffer from acute ischemic stroke within 1 year after the diagnosis of lung cancer (41 cases, 80.39%).

Conclusions

Hypercoagulability and acute multiple brain infarcts were more common in patients with LCA-AIS, and hypoproteinemia and hyponatremia were more likely to occur in these patients, leading to worse prognosis. Patients were most likely to have a stroke within 1 year after the diagnosis of lung cancer.

中文翻译：

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肺癌相关急性缺血性卒中的临床特征和分析。

介绍

近年来，肺癌和急性缺血性中风的发生率仍然很高，这两种情况大多发生在60岁以上的人群中。在本研究中，我们旨在通过比较和分析有或没有肺癌的中风患者的临床特征，进一步阐明肺癌相关的急性缺血性中风（LCA-AIS）的发病机制。

方法

选择51例肺癌患者作为病例组（LCSG），将78例无癌病史的患者作为对照组（SG）。该研究收集的数据包括性别，年龄，传统脑血管疾病危险因素（TCDRF），血液检查指标，影像学发现，病因分型和预后评估。使用SPSS21.0软件进行统计分析。通过t检验分析正态分布的数据，通过卡方检验或精确概率法分析计数数据。P  <0.05被认为具有统计学意义。

结果

在病例组中，血浆D-二聚体，纤维蛋白原降解产物（FDPs）和NIHSS的水平以及患者的mRS评分和死亡率均较高，而RBC，Hb和Hcy的水平则较低。控制组。影像学检查结果显示，多发性血管受累在病例组中更为常见，梗塞更可能是多发性的，并涉及前循环和后循环。LCSG的TOAST分类主要由未定病因（SUE）和其他确定病因（SOE）引起。统计分析表明，在诊断出肺癌后的一年内，患者更有可能患急性缺血性中风（41例，占80.39％）。

结论

高凝性和急性多发性脑梗死在LCA-AIS患者中更为常见，低蛋白血症和低钠血症更可能发生在这些患者中，导致预后较差。诊断肺癌后的一年内，患者最有可能中风。