Inflammatory responses stimulated by Propionibacterium acnes have been shown to be major etiological factors in the pathogenesis of acne. Scutellaria baicalensis, a popular traditional Chinese medicine, has been widely shown to have anti-inflammatory effects. In this study, primary component analysis and primary effective component analysis were conducted. The results showed that wogonin (1.15 mg/g S. baicalensis extract) possessed better anti-acne effects than wogonoside (8.71 mg/g S. baicalensis extract) in inhibiting the up-regulation of IL-1β and IL-8 level caused by P. acnes via inactivation of the MAPK and NF-κB signaling pathways. To enhance the anti-acne effects of S. baicalensis extract, an environmentally friendly and healthy plant fermentation strategy was used to efficiently convert glycoside-type constituents into bioactive aglycone. S. baicalensis extract was fermented by symbiotic fungus Penicillium decumbens f3-1 to transform wogonoside into wogonin with a conversion rate of 91.0% after 4 days. Fermented S. baicalensis extract (FSE) showed higher potential anti-acne effects than non-fermented S. baicalensis extract (NSE) by inhibiting the up-regulation of IL-1β and IL-8. Thus, P. decumbens-fermented S. baicalensis Extract may be used for developing new anti-acne cosmetic ingredients.

痤疮丙酸杆菌刺激的炎症反应已被证明是痤疮发病机理中的主要病因。黄cut，一种流行的中药，已被广泛证明具有抗炎作用。在这项研究中，进行了主要成分分析和主要有效成分分析。结果表明，wogonin（1.15 mg / g黄ical提取物）在抑制痤疮引起的IL-1β和IL-8水平上调方面比wogonoside（8.71 mg / g黄。提取物）具有更好的抗粉刺作用。痤疮丙酸杆菌可通过失活MAPK和NF-κB信号通路来实现。增强黄ba的抗粉刺作用提取物，一种环境友好和健康的植物发酵策略用于有效地将糖苷类成分转化为具有生物活性的糖苷配基。用共生真菌青霉青霉f3-1发酵黄extract提取物，将wogonoside转化为wogonin，4天后转化率为91.0％。通过抑制IL-1β和IL-8的上调，发酵的黄ba提取物（FSE）比未发酵的黄。提取物（NSE ）具有更高的潜在抗粉刺作用。因此，腐烂假单胞菌发酵的黄ba提取物可用于开发新的抗痤疮化妆品成分。