A promising chemotherapeutic agent is spirooxindole. Probable targets involve cancers of the lung, liver, breast, colon, stomach, and prostate. Widespread drug discovery applications and biological activity are significant synthetic targets of spirooxindoles. In the present study, the synthesis of CaFe₂O₄ nanoparticles via the sol–gel method is discussed. Vibrating sample magnetometer, scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction were used to prepare and characterize CaFe₂O₄@MgAl-LDH as an effective catalyst for the preparation of spirooxindole derivatives via one-pot, the three-component reaction of malononitrile, CH-acids (1,3-dicarbonyl compounds), and isatin in the presence of CaFe₂O₄@MgAl-LDH in excellent yields with short reaction times in aqueous media is used to describe a facile and efficient multicomponent synthesis of functionalized spirooxindoles.

有希望的化学治疗剂是螺环吲哚。可能的靶标涉及肺癌，肝癌，乳腺癌，结肠癌，胃癌和前列腺癌。广泛的药物发现应用和生物活性是螺硫醇的重要合成靶标。在本研究中，讨论了通过溶胶-凝胶法合成CaF​​e ₂ O ₄纳米粒子。使用振动样品磁力计，扫描电子显微镜，傅立叶变换红外光谱和X射线衍射来制备和表征CaFe ₂ O ₄ @ MgAl-LDH，作为通过一锅，三锅，三锅和四锅的方法制备螺喔啉衍生物的有效催化剂。 CaFe存在下丙二腈，CH-酸（1,3-二羰基化合物）和靛红的组分反应₂ O ₄ @ MgAl-LDH在水性介质中以极高的收率和短的反应时间被用来描述功能化螺硫醇的简便有效的多组分合成。