The possibility of development of dependence was studied during the intermittent consumption of sucrose, sodium chloride, and sodium glutamate solutions. Rats were allowed to choose and consume solutions of sucrose, sodium chloride, and sodium glutamate for 28 days. On days 29-31 of the experiment, the animals were deprived of the preferred solutions. On days 32-33, the solutions of sucrose, sodium chloride, and sodium glutamate, but not water were provided again. The consumption of sucrose and sodium chloride solutions did not increase, but consumption of 0.5 and 1% sodium glutamate solutions increased after 3-days withdrawal. The consumption of 2% solution of sodium glutamate was the same before and after withdrawal. The observed effects of sodium glutamate deprivation probably indicate the development of pathological glutamate dependence.

中文翻译：

---

间断使用谷氨酸钠而不是蔗糖或氯化钠溶液后病理依赖性的发展

在蔗糖、氯化钠和谷氨酸钠溶液的间歇消耗期间研究了依赖性发展的可能性。允许大鼠选择和消耗蔗糖、氯化钠和谷氨酸钠溶液28天。在实验的第 29-31 天，动物被剥夺了首选溶液。在第 32-33 天，再次提供蔗糖、氯化钠和谷氨酸钠溶液，但不提供水。蔗糖和氯化钠溶液的消耗量没有增加，但 0.5% 和 1% 谷氨酸钠溶液的消耗量在停药 3 天后增加。2%谷氨酸钠溶液停药前后用量相同。观察到的谷氨酸钠剥夺的影响可能表明病理性谷氨酸依赖的发展。