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Low dose lung radiation therapy for pneumonia: an examination of historical dose distributions
Physics in Medicine & Biology ( IF 3.5 ) Pub Date : 2020-07-30 , DOI: 10.1088/1361-6560/ab9e55
Charles Kirkby 1, 2, 3, 4 , Marc Mackenzie 5
Affiliation  

The novel coronavirus, SARS-CoV-2, that causes the COVID-19 disease currently has healthcare systems around the world dealing with unprecedented numbers of critically ill patients. One of the primary concerns associated with this illness is acute respiratory distress syndrome (ARDS) and the pneumonia that accompanies it. Historical literature dating back to the 1940s and earlier contains many reports of successful treatment of pneumonias with ionizing radiation. Although these were not randomized controlled trials, they do suggest a potential avenue for further investigation. Technical details in these reports however were limited. In this work we review the literature and identify details including nominal kilovoltage ranges, filtration, and focus-skin distances (FSDs). Using a freely available and benchmarked code, we generated spectra and used these as sources for Monte Carlo simulations using the EGSnrc software package. The approximate sources were projected through a radio...

中文翻译:

低剂量肺放射治疗肺炎:历史剂量分布检查

导致COVID-19病的新型冠状病毒SARS-CoV-2目前在世界范围内拥有处理史无前例的重症患者的医疗保健系统。与这种疾病有关的主要问题之一是急性呼吸窘迫综合征(ARDS)和随之而来的肺炎。追溯到1940年代及更早的历史文献包含许多通过电离辐射成功治疗肺炎的报道。尽管这些不是随机对照试验,但确实为进一步研究提供了潜在途径。但是,这些报告中的技术细节有限。在这项工作中,我们回顾了文献并确定了细节,包括标称千伏范围,滤波和聚焦皮肤距离(FSD)。使用免费提供的基准代码,我们生成了光谱,并将其用作使用EGSnrc软件包进行蒙特卡洛模拟的源。大概的信号源是通过收音机投影的。
更新日期:2020-07-31
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