The current study aimed to investigate the therapeutic effects of 5,7-dihydroxy-6-oxoheptadecanoic acid (DHA) from Tiliacora triandra on rat models of type 2 diabetes mellitus (T2DM). T2DM was induced with a combination of high-fat diet/streptozotocin (HFD/STZ), and diabetic rats were treated with DHA (25 mg/kg) for 30 days. The body weight, fasting blood glucose (FBG), serum, and liver biochemical parameters, as well as histological evaluations of the liver and pancreas, were evaluated. Diabetic rats displayed a significant increase in FBG, serum lipid profiles (triglycerides, total cholesterol, and low-density lipoprotein cholesterol), liver function enzymes (aspartate transaminase, alkaline phosphatase, and alanine transaminase), creatinine, liver malondialdehyde (MDA), and myeloperoxidase (MPO) contents. Furthermore, insulin level and liver antioxidant enzyme activities (catalase [CAT], superoxide dismutase [SOD], and glutathione peroxidase [GSH-Px]) were significantly reduced in the diabetic rats. Whereas, treatment with DHA significantly reduced FBG, serum lipids, liver function enzymes, serum creatinine, liver MDA, and MPO contents. In addition, treatment with DHA significantly increased serum insulin level and liver SOD, CAT, and GSH-Px activities. In addition, DHA alleviated histopathological changes in the pancreas and liver caused by T2DM. These results portray the antidiabetic and antioxidative properties of DHA and can be considered as a potential treatment for T2DM.

当前的研究旨在研究from虫中5,7-二羟基-6-氧庚二酸（DHA）的治疗作用在2型糖尿病（T2DM）的大鼠模型上。高脂饮食/链脲佐菌素（HFD / STZ）联合诱导T2DM，并用DHA（25 mg / kg）治疗糖尿病大鼠30天。评估了体重，空腹血糖（FBG），血清和肝脏生化参数，以及肝脏和胰腺的组织学评估。糖尿病大鼠的FBG，血脂水平（甘油三酸酯，总胆固醇和低密度脂蛋白胆固醇），肝功能酶（天冬氨酸转氨酶，碱性磷酸酶和丙氨酸转氨酶），肌酐，肝丙二醛（MDA）和髓过氧化物酶（MPO）含量。此外，胰岛素水平和肝脏抗氧化酶活性（过氧化氢酶[CAT]，超氧化物歧化酶[SOD]，和糖尿病大鼠的谷胱甘肽过氧化物酶和谷胱甘肽过氧化物酶[GSH-Px]）明显降低。而用DHA治疗可显着降低FBG，血清脂质，肝功能酶，血清肌酐，肝脏MDA和MPO含量。此外，用DHA治疗可显着提高血清胰岛素水平以及肝脏SOD，CAT和GSH-Px活性。另外，DHA减轻了由T2DM引起的胰腺和肝脏的组织病理学变化。这些结果说明了DHA的抗糖尿病和抗氧化特性，可以认为是T2DM的潜在治疗方法。另外，DHA减轻了由T2DM引起的胰腺和肝脏的组织病理学变化。这些结果说明了DHA的抗糖尿病和抗氧化特性，可以认为是T2DM的潜在治疗方法。另外，DHA减轻了由T2DM引起的胰腺和肝脏的组织病理学变化。这些结果说明了DHA的抗糖尿病和抗氧化特性，可以认为是T2DM的潜在治疗方法。