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Multi-Arm Star-Shaped Glycopolymers with Precisely Controlled Core Size and Arm Length.
Biomacromolecules ( IF 6.2 ) Pub Date : 2020-07-30 , DOI: 10.1021/acs.biomac.0c00838
Alessandra Monaco 1, 2 , Valentin P Beyer 1, 2 , Richard Napier 3 , C Remzi Becer 2
Affiliation  

Star-shaped glycopolymers provide very high binding activities toward lectins. However, a straightforward synthesis method for the preparation of multi-arm glycopolymers in a one-pot approach has been challenging. Herein, we report a rapid synthesis of well-defined multi-arm glycopolymers via Cu(0)-mediated reversible deactivation radical polymerization in aqueous media. d-Mannose acrylamide has been homo- and copolymerized with NIPAM to provide linear arms and then core cross-linked with a bisacrylamide monomer. Thus, the arm length and core size of multi-arm glycopolymers were tuned. Moreover, the stability of multi-arm glycopolymers was investigated, and degradation reactions under acidic or basic conditions were observed. The binding activities of the obtained multi-arm glycopolymers with mannose-specific human lectins, DC-SIGN and MBL, were investigated via surface plasmon resonance spectroscopy. Finally, the encapsulation ability of multi-arm glycopolymers was examined using DHA and Saquinavir below and above the lower critical solution temperature (LCST) of P(NIPAM).

中文翻译:

具有精确控制的纤芯尺寸和臂长的多臂星形糖质共聚物。

星形糖聚合物对凝集素具有很高的结合活性。然而,以一锅法制备多臂糖类聚合物的简单合成方法一直具有挑战性。在这里,我们报告通过Cu(0)介导的可逆失活自由基聚合在水性介质中的快速定义的多臂糖聚合物的快速合成。d-甘露糖丙烯酰胺已经与NIPAM均聚并共聚以提供线性臂,然后核芯与双丙烯酰胺单体交联。因此,调整了多臂糖聚合物的臂长和核心大小。此外,研究了多臂糖聚合物的稳定性,并观察了在酸性或碱性条件下的降解反应。通过表面等离子体共振光谱研究了获得的多臂糖聚合物与甘露糖特异性人凝集素DC-SIGN和MBL的结合活性。最后,在P(NIPAM)的较低临界溶液温度(LCST)之上和之下,使用DHA和Saquinavir检测了多臂糖基聚合物的包封能力。
更新日期:2020-09-14
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