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The modulating impact of cigarette smoking on brain structure in panic disorder: a voxel-based morphometry study.
Social Cognitive and Affective Neuroscience ( IF 4.2 ) Pub Date : 2020-07-30 , DOI: 10.1093/scan/nsaa103
Stefanie L Kunas 1, 2 , Kevin Hilbert 1 , Yunbo Yang 3 , Jan Richter 4 , Alfons Hamm 4 , André Wittmann 2 , Andreas Ströhle 2 , Bettina Pfleiderer 5 , Martin J Herrmann 6 , Thomas Lang 7, 8 , Martin Lotze 9 , Jürgen Deckert 6 , Volker Arolt 10 , Hans-Ulrich Wittchen 11 , Benjamin Straube 3 , Tilo Kircher 3 , Alexander L Gerlach 3 , Ulrike Lueken 1
Affiliation  

Abstract
Cigarette smoking increases the likelihood of developing anxiety disorders, among them panic disorder (PD). While brain structures altered by smoking partly overlap with morphological changes identified in PD, the modulating impact of smoking as a potential confounder on structural alterations in PD has not yet been addressed. In total, 143 PD patients (71 smokers) and 178 healthy controls (62 smokers) participated in a multicenter magnetic resonance imaging (MRI) study. T1-weighted images were used to examine brain structural alterations using voxel-based morphometry in a priori defined regions of the defensive system network. PD was associated with gray matter volume reductions in the amygdala and hippocampus. This difference was driven by non-smokers and absent in smoking subjects. Bilateral amygdala volumes were reduced with increasing health burden (neither PD nor smoking > either PD or smoking > both PD and smoking). As smoking can narrow or diminish commonly observed structural abnormalities in PD, the effect of smoking should be considered in MRI studies focusing on patients with pathological forms of fear and anxiety. Future studies are needed to determine if smoking may increase the risk for subsequent psychopathology via brain functional or structural alterations.


中文翻译:

吸烟对恐慌症大脑结构的调节作用:一项基于体素的形态学研究。

摘要
吸烟增加了发生焦虑症(包括恐慌症)的可能性。尽管因吸烟而改变的大脑结构与PD中鉴定出的形态学变化部分重叠,但吸烟作为PD潜在结构改变的潜在混杂因素的调节作用尚未得到解决。总共143名PD患者(71名吸烟者)和178名健康对照(62名吸烟者)参加了多中心磁共振成像(MRI)研究。T1加权图像用于在防御系统网络的先验定义区域中使用基于体素的形态计量学检查大脑结构改变。PD与杏仁核和海马体中灰质物质的减少有关。这种差异是由不吸烟者和吸烟对象缺席所致。随着健康负担的增加,双侧杏仁核体积减少(PD或吸烟都不> PD或吸烟> PD和吸烟都没有)。由于吸烟可以缩小或减少PD中通常观察到的结构异常,因此在MRI研究中应考虑吸烟的影响,该研究重点是具有恐惧和焦虑的病理形式的患者。需要进行进一步的研究以确定吸烟是否会通过脑功能或结构改变而增加随后发生精神病的风险。
更新日期:2020-10-08
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