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Brain microstructural changes and cognitive function in non-demented essential tremor patients: a diffusion tensor imaging study
International Journal of Neuroscience ( IF 2.2 ) Pub Date : 2020-08-06 , DOI: 10.1080/00207454.2020.1803859
Y Sengul 1, 2 , H O Temur 3 , Z Corakcı 4 , H S Sengul 5 , H Dowd 2 , I Ustun 1 , A Alkan 3 , E D Louis 2, 6, 7
Affiliation  

Abstract

Background

Essential tremor (ET) is disease with both motor and non-motor features. Notable among the non-motor features is cognitive impairment. While this impairment has been attributed to cortico-thalamo-cerebellar pathway pathology, it is likely that a more complicated involvement of brain structures underlies cognitive function in ET.

Objective

To evaluate the brain microstructural changes of both white matter and grey matter in ET using region of interest based diffusion tensor imaging (DTI), and to correlate these changes with cognitive function assessed during detailed neuropsychological testing.

Method

Thirty-five non-demented ET patients with a range of cognitive function (Clinical Dementia Rating = 0–0.5, mean age = 57.5 ± 16.7 years, age range = 23–76 years) underwent a comprehensive neuropsychological evaluation and brain magnetic resonance imaging, including DTI. DTI findings were reported as fractional anisotropy, average diffusion coefficient, these values were evaluated for 32 ROIs. Cognitive domains included attention, visuospatial functions, executive function, verbal memory, visual memory, and language. Domain Z-scores were calculated each cognitive domain and compared for each brain region.

Results

Microstructural changes in prefrontal cortical areas (dorsolateral, ventrolateral), paralimbic and limbic structures (posterior cingulate cortex, precuneus, hippocampus), basal ganglia (substantia nigra, putamen, caudate nucleus) and white matter bundles (corpus callosum, anterior thalamic radiation, longitudinal fasciculus, frontooccipital fasciculus, etc.) correlated with specific domains of cognitive function in ET patients.

Conclusion

These data suggest that not only the cerebello thalamocortical pathway, but numerous other brain structures are related to level of cognitive performance and possibly underlie cognitive dysfunction in ET.



中文翻译:

非痴呆特发性震颤患者的脑微结构变化和认知功能:扩散张量成像研究

摘要

背景

特发性震颤 (ET) 是具有运动和非运动特征的疾病。非运动特征中值得注意的是认知障碍。虽然这种损伤归因于皮质-丘脑-小脑通路病理学,但更复杂的脑结构参与可能是 ET 认知功能的基础。

客观的

使用基于感兴趣区域的扩散张量成像 (DTI) 评估 ET 中白质和灰质的脑微结构变化,并将这些变化与详细神经心理学测试期间评估的认知功能相关联。

方法

35 名具有一系列认知功能的非痴呆 ET 患者(临床痴呆评分 = 0-0.5,平均年龄 = 57.5 ± 16.7 岁,年龄范围 = 23-76 岁)接受了全面的神经心理学评估和脑磁共振成像,包括 DTI。DTI 结果报告为分数各向异性、平均扩散系数,这些值针对 32 个 ROI 进行了评估。认知领域包括注意力、视觉空间功能、执行功能、语言记忆、视觉记忆和语言。计算每个认知域的域 Z 分数,并针对每个大脑区域进行比较。

结果

前额叶皮层(背外侧、腹外侧)、旁边缘和边缘结构(后扣带皮层、楔前叶、海马)、基底神经节(黑质、壳核、尾状核)和白质束(胼胝体、前丘脑辐射、纵向束、额枕束等)与 ET 患者认知功能的特定领域相关。

结论

这些数据表明,不仅小脑丘脑皮质通路,而且许多其他大脑结构都与认知表现水平相关,并且可能是 ET 认知功能障碍的基础。

更新日期:2020-08-06
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