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Prognostic value of baseline APACHE II score combined with uric acid concentration for short-term clinical outcomes in patients with sepsis
Frontiers in Life Science ( IF 1.333 ) Pub Date : 2020-07-31 , DOI: 10.1080/26895293.2020.1796828
Lan Gao 1 , Qindong Shi 1 , Hao Li 1 , Qinyue Guo 1 , Jinqi Yan 1
Affiliation  

To our knowledge, no study to date has assessed the ability of baseline Acute Physiology and Chronic Health Evaluation (APACHE) II score plus uric acid (UA) concentration to predict short-term clinical outcomes in patients with sepsis. This single-center retrospective cohort study analyzed 432 patients with sepsis who were followed up for at least 30-days between January 2016 and December 2018. The endpoint was death from any cause. Patients were categorized into four groups according to baseline APACHE II score and UA concentration, and the relationships between these parameters and all-cause in-hospital and 30-day mortality rates were analyzed. The in-hospital and 30-day all-cause mortality rates were 23.1% and 31.5%, respectively. Cox proportional hazard analysis showed that, after adjustment for confounding factors, APACHE II score ≥17.5 plus UA concentration ≥296.27 µmol/L were independently predictive of 30-day mortality (adjusted Model 1: hazard ratio [HR]=9.30, P=0.001; adjusted Model 2: HR=5.01, P=0.019). APACHE II score plus UA concentration was a strong independent predictor of short-term clinical outcomes in patients with sepsis. A higher APACHE II score plus higher UA concentration was significantly associated with adverse short-term outcomes.



中文翻译:

基线APACHE II评分结合尿酸浓度对败血症患者短期临床预后的预后价值

据我们所知,迄今为止,尚无研究评估基线急性生理和慢性健康评估(APACHE)II评分加尿酸(UA)浓度预测脓毒症患者短期临床结局的能力。这项单中心回顾性队列研究分析了2016年1月至2018年12月之间至少进行了30天随访的432名败血症患者。终点为任何原因的死亡。根据基线APACHE II评分和UA浓度将患者分为四组,并分析这些参数与全因住院和30天死亡率之间的关系。住院和30天全因死亡率分别为23.1%和31.5%。考克斯比例风险分析表明,在调整混杂因素后,APACHE II评分≥17。P = 0.001;调整后的模型2:HR = 5.01,P = 0.019)。APACHE II评分加UA浓度是脓毒症患者短期临床预后的有力独立预测指标。较高的APACHE II评分加上较高的UA浓度与不良的短期预后显着相关。

更新日期:2020-07-31
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