Background

Colorectal cancer (CRC) is a leading cause of cancer-related death. Epithelial-mesenchymal transition (EMT) is a major process in tumor metastasis development. This systematic review aims to describe the role of long non-coding RNA (lncRNA) in EMT in CRC.

Methods

The electronic databases, PubMed, Cochrane, and EMBASE, were searched from January1990 to June 2019 to identify studies examining lncRNA and their role in mediating EMT in CRC. Studies examining clinical specimens and/or in vitro experiments were included.

Results

In 61 identified studies, 54 lncRNAs were increased in CRC compared to normal colorectal epithelium. Increased lncRNA expression was frequently associated with worse survival. Many lncRNAs mediate their effect through competitive endogenous RNA or transcription factor regulation. The ZEB1, 2/E-cadherin, Wnt/β-catenin signaling, and chromatin remodeling pathways are discussed in particular.

Conclusions

lncRNAs are major regulators of EMT and predictor adverse outcome in CRC patients. Future research must focus on delineating lncRNA function prior to potential clinical use.

中文翻译：

---

结直肠癌中的长链非编码 RNA (lncRNA) 和上皮间质转化 (EMT)：系统评价。

背景

结直肠癌 (CRC) 是癌症相关死亡的主要原因。上皮间质转化（EMT）是肿瘤转移发展的主要过程。本系统综述旨在描述长链非编码 RNA (lncRNA) 在 CRC 的 EMT 中的作用。

方法

从 1990 年 1 月到 2019 年 6 月检索了 PubMed、Cochrane 和 EMBASE 电子数据库，以确定检查 lncRNA 及其在 CRC 中介导 EMT 中的作用的研究。包括检查临床标本和/或体外实验的研究。

结果

在 61 项确定的研究中，与正常结直肠上皮相比，CRC 中有 54 种 lncRNA 增加。lncRNA 表达增加通常与较差的存活率相关。许多 lncRNA 通过竞争性内源性 RNA 或转录因子调节来介导它们的作用。特别讨论了 ZEB1、2/E-钙粘蛋白、Wnt/β-连环蛋白信号传导和染色质重塑途径。

结论

lncRNAs 是 CRC 患者 EMT 的主要调节因子和预测不良结果。未来的研究必须专注于在潜在临床使用之前描绘 lncRNA 功能。