One of the major challenges for the treatment of osteoarthritis (OA) with therapeutic drugs is the short half-life of drugs in the joint cavity. The severity of OA often fluctuates with time and inflammatory factors. Here, we describe the use of a hydrogel material, named Gel-Man, to solve the problem of rapid release of drugs. Gel-Man could encapsulate a series of therapeutic drugs and be degraded by hydrogen peroxide. It could be decomposed, and release drugs controlled by the concentration of hydrogen peroxide in the arthritic joint cavity. This hydrogel loaded with triamcinolone acetonide (TA) could slowly release the drug upon exposure to hydrogen peroxide in the joint cavity in patients suffering from osteoarthritis. The combination of TA and GEL-MAN hydrogels can slowdown the progression of degenerative change of osteoarthritis by maximizing the therapeutic efficacy and prolong the duration of drug treatment.

中文翻译：

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载有曲安奈德的 GEL-MAN 水凝胶治疗骨关节炎

用治疗药物治疗骨关节炎 (OA) 的主要挑战之一是药物在关节腔内的半衰期短。OA 的严重程度通常随时间和炎症因素而波动。在这里，我们描述了使用名为 Gel-Man 的水凝胶材料来解决药物快速释放的问题。Gel-Man 可以封装一系列治疗药物，并被过氧化氢降解。它可以分解，释放受关节炎关节腔内过氧化氢浓度控制的药物。这种载有曲安奈德 (TA) 的水凝胶可以在骨关节炎患者的关节腔中暴露于过氧化氢后缓慢释放药物。