Cannabinoids hold promise for treating health problems related to inflammation and chronic pain in dogs, in particular cannabidiol (CBD), and its native acid derivative cannabidiolic acid (CBDA). Information regarding systemic delivery of cannabinoids through transdermal routes is sparse. The purpose of this study was to determine pharmacokinetics of transdermal administration of a low‐THC Cannabis sativa extract in healthy dogs. Six purpose‐bred research beagles were treated with a transdermal CBD‐CBDA‐rich extract, and serum concentrations of CBD, CBDA, tetrahydrocannabinol (THC), and its acid derivative tetrahydrocannabinolic acid (THCA) were examined prior to and at the end of weeks 1 and 2. A 4 mg/kg dose of total cannabinoids twice daily resulted in appx 10 ng/ml of CBD, 21–32 ng/ml of CBDA, trace amounts of THCA, and unquantifiable amounts of THC in serum at the end of weeks 1 and 2 of treatment. Results showed that CBDA and THCA were absorbed better systemically than CBD or THC.

中文翻译：

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在小猎犬体内经皮施用低THC大麻苜蓿提取物后，血清大麻二酚，四氢大麻酚（THC）及其天然酸衍生物。

大麻素有望用于治疗与狗的炎症和慢性疼痛有关的健康问题，特别是大麻素（CBD）及其天然酸衍生物大麻二酸（CBDA）。有关通过经皮途径全身性输送大麻素的信息很少。这项研究的目的是确定低THC大麻苜蓿经皮给药的药代动力学在健康的狗中提取。六只专门研究的小猎犬用富含CBD-CBDA的经皮提取物处理，并在每周之前和结束时检查了CBD，CBDA，四氢大麻酚（THC）及其酸衍生物四氢大麻酚（THCA）的血清浓度1和2。每天两次两次4 mg / kg剂量的总大麻素导致大约10 ng / ml的CBD，21–32 ng / ml的CBDA，痕量的THCA和血清中无法定量的THC。治疗的第1周和第2周。结果表明，CBDA和THCA的吸收比CBD或THC更好。