NK1.1⁺ cells found in salivary glands (SG) represent a unique cell population of innate lymphoid cells (ILC) with characteristics of both conventional NK cells and ILC1. Here, we demonstrate that these NK1.1⁺ cells limit the accumulation and differentiation of virus‐specific tissue‐resident memory CD8⁺ T cells (T_RM cells) in SG of mice infected with lymphocytic choriomeningitis virus (LCMV). The negative regulation of LCMV‐specific CD8⁺ T_RM cells by NK1.1⁺ cells in SG is independent of NKG2D, NKp46, TRAIL, and perforin. Moreover, analysis of NKp46^iCre+Eomes^fl/fl mice revealed that Eomes‐dependent conventional NK cells are dispensable for negative regulation. Since the SG are prone to autoimmune reactions, regulation of T_RM cells by tissue‐resident ILC may be particularly important to prevent immunopathology in this organ.

中文翻译：

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唾液腺中的NK1.1 +先天性淋巴样细胞抑制小鼠中组织驻留记忆CD8 + T细胞的建立。

在唾液腺（SG）中发现的NK1.1 ⁺细胞代表具有传统NK细胞和ILC1特征的先天性淋巴样细胞（ILC）的独特细胞群。在这里，我们证明这些NK1.1 ⁺ 细胞限制了 感染了淋巴细胞性脉络膜脑膜炎病毒（LCMV）的小鼠的SG中病毒特异性组织驻留记忆CD8 ⁺ T细胞（T _RM细胞）的积累和分化。 SG中 NK1.1 ⁺细胞对LCMV特异性CD8 ⁺ T _RM细胞的负调控独立于NKG2D，NKp46，TRAIL和穿孔素。此外，NKp46 ^{iCre +} Eomes ^{fl / fl的分析}小鼠显示，依赖Eomes的常规NK细胞可用于负调节。由于SG很容易发生自身免疫反应，因此 通过组织驻留ILC调节T _RM细胞对于预防该器官的免疫病理可能特别重要。