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Apatite matrix substituted with biologically essential rare earth elements as an artificial hard tissue substitute: Systematic physicochemical and biological evaluation
Journal of Biomedical Materials Research Part A ( IF 4.9 ) Pub Date : 2020-07-30 , DOI: 10.1002/jbm.a.37069
Likha Chandran 1 , Ballamurugan Am 1
Affiliation  

Hydroxyapatite (HAP) forms the main inorganic component of natural bone and hence has been widely use in implant applications. Ionic substitutions in apatite also gains enormous interest during the recent years due to the crucial role played by these elements in the biological process. In this context, the least investigated elements namely lanthanum (La3+) and praseodymium (Pr3+) have been selected as a potential substitutions in apatite. The results from the analytical techniques confirm the phase purity of the HAP and its ability holds the substitutions at its lattice. Morphological analysis unveils the presence of agglomerated spheroids notwithstanding the ion concentration of substituents. EDX spectra affirm the presence of La and Pr alongside the determined Ca/P atomic ratio of 1.67. La3+ and Pr3+ presence envisaged the good antibacterial efficiency against the tested microbes and further demonstrated the biocompatibility nature from the cytotoxicity analysis.

中文翻译:

用生物必需的稀土元素取代磷灰石基质作为人工硬组织替代品:系统的理化和生物学评价

羟基磷灰石 (HAP) 是天然骨的主要无机成分,因此已广泛用于植入物应用。由于这些元素在生物过程中发挥的关键作用,近年来磷灰石中的离子取代也引起了极大的兴趣。在这方面,研究最少的元素是镧 (La 3+ ) 和镨 (Pr 3+) 已被选为磷灰石中的潜在替代品。分析技术的结果证实了 HAP 的相纯度及其在其晶格上保持取代的能力。尽管取代基的离子浓度,形态分析揭示了团聚球体的存在。EDX 光谱证实了 La 和 Pr 的存在,同时确定的 Ca/P 原子比为 1.67。La 3+和Pr 3+ 的存在预示着对测试微生物的良好抗菌效率,并进一步证明了细胞毒性分析的生物相容性。
更新日期:2020-07-30
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