Cancer, even currently, is one of the main reasons for mortality and morbidity, worldwide. In recent years, a great deal of effort has been made to find efficient therapeutic strategies for cancer, however, particularly with regards to side effects and the possibility of complete remission. Berberine (BBR) is a nature‐driven phytochemical component originated from different plant groups such as Berberis vulgaris, Berberis aquifolium, and Berberis aristata. BBR is a well‐known nutraceutical because of its wide range of pharmacological activities including anti‐inflammatory, antidiabetic, antibacterial, antiparasitic, antidiarrheal, antihypertensive, hypolipidemic, and fungicide. In addition, it exhibits inhibitory effects on multiple types of cancers. In this review, we have elaborated on the anticancer effects of BBR through the regulation of different molecular pathways such as: inducing apoptosis, autophagy, arresting cell cycle, and inhibiting metastasis and invasion.

中文翻译：

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小檗碱：一种新的癌症治疗策略

癌症，即使是目前，也是世界范围内死亡率和发病率的主要原因之一。近年来，人们做出了大量努力来寻找有效的癌症治疗策略，尤其是在副作用和完全缓解的可能性方面。小檗碱 (BBR) 是一种自然驱动的植物化学成分，来源于不同的植物群，如小檗、小檗和小檗。BBR 是一种众所周知的营养保健品，因为它具有广泛的药理活性，包括抗炎、抗糖尿病、抗菌、抗寄生虫、止泻、抗高血压、降血脂和杀真菌剂。此外，它还对多种类型的癌症具有抑制作用。在这次审查中，