The epicardium is the outer mesothelial layer of the heart. It encloses the myocardium and plays key roles in heart development and regeneration. It derives from the proepicardium (PE), cell clusters that appear in the dorsal pericardium (DP) close to the atrioventricular canal and the venous pole of the heart, and are released into the pericardial cavity. PE cells are advected around the beating heart until they attach to the myocardium. Bmp and Notch signaling influence PE formation, but it is unclear how both signaling pathways interact during this process in the zebrafish.

中文翻译：

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Notch和Bmp信号通路在心外膜形成过程中协同作用

心外膜是心脏的外间皮层。它包裹着心肌，在心脏发育和再生中起关键作用。它来源于心外膜前体（PE），细胞团出现在靠近房室管和心脏静脉极的背心包膜（DP）中，并释放到心包腔中。PE 细胞在跳动的心脏周围平流，直到它们附着在心肌上。Bmp 和 Notch 信号会影响 PE 的形成，但尚不清楚这两种信号通路在斑马鱼的这一过程中是如何相互作用的。