Recent studies suggest that the tetracycline antibiotic minocycline, or its cousins, hold therapeutic potential for affective and psychotic disorders. This is proposed on the basis of a direct effect on microglia‐mediated frontocortical synaptic pruning (FSP) during adolescence, perhaps in genetically susceptible individuals harboring risk alleles in the complement component cascade that is involved in this normal process of CNS circuit refinement. In reviewing this field, it is argued that minocycline is actually probing and modulating a deeply evolved and intricate system wherein psychosocial stimuli sculpt the circuitry of the “social brain” underlying adult behavior and personality. Furthermore, this system can generate psychiatric morbidity that is not dependent on genetic variation. This view has important ramifications for understanding “pathologies” of human social behavior and cognition as well as providing long‐sought potential mechanistic links between social experience and susceptibility to mental and physical disease.

中文翻译：

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精神分裂症中的突触修剪：米诺环素是否调节心理社会大脑发育？

最近的研究表明，四环素抗生素米诺环素或其表亲对情感障碍和精神障碍具有治疗潜力。这是基于对青春期小胶质细胞介导的额皮质突触修剪 (FSP) 的直接影响而提出的，可能是在补体成分级联中存在风险等位基因的遗传易感个体中，而补体成分级联涉及这一正常的 CNS 电路细化过程。在回顾这个领域时，有人认为米诺环素实际上是在探索和调节一个深度进化和复杂的系统，其中心理社会刺激塑造了成人行为和个性背后的“社会大脑”电路。此外，该系统可以产生不依赖于遗传变异的精神病发病率。