当前位置: X-MOL 学术Epilepsy Behav. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Trait impulsivity correlates with active myoclonic seizures in genetic generalized epilepsy
Epilepsy & Behavior ( IF 2.6 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.yebeh.2020.107260
Marte Syvertsen 1 , Jeanette Koht 1 , Kaja Selmer 2 , Ulla Enger 3 , Deb K Pal 4 , Anna Smith 4
Affiliation  

BACKGROUND Juvenile myoclonic epilepsy (JME) is a common subtype of genetic generalized epilepsy (GGE) arising in adolescence and is often associated with executive function (EF) deficits. Some EF components like response inhibition have been extensively evaluated in JME, but few studies have focused upon trait impulsivity or compared between GGE subtypes. The aim of the present study was to compare the association of trait impulsivity in JME with other GGE subtypes. METHODS Patients with GGE aged between 14 and 40 years (n = 137) were divided into those with JME (n = 92) and those with other GGEs (n = 45: 8 childhood absence epilepsy (CAE), 22 juvenile absence epilepsy (JAE), and 15 epilepsy with generalized tonic-clonic seizures only (EGTCS)). The study participants were recruited through medical records of the general population of Buskerud County and the neighboring municipalities, covering 477,000 people or 9.1% of Norway's total population. All participants underwent a clinical interview including the Barratt Impulsiveness Scale (BIS), an established measure of trait impulsivity. We controlled for other potential predictors of BIS score using analysis of covariance (ANCOVA). RESULTS There were no differences between JME and other types of GGE for BIS scores, but the presence of myoclonic seizures within the last year, irrespective of GGE subtype, was independently associated with significantly increased behavioral impulsivity. CONCLUSIONS This study demonstrates that trait impulsivity in GGE is most strongly related to the recent occurrence of myoclonic seizures rather than GGE subtype.

中文翻译:

遗传性全身性癫痫的性状冲动与活动性肌阵挛发作相关

背景青少年肌阵挛性癫痫 (JME) 是发生于青春期的遗传性全身性癫痫 (GGE) 的常见亚型,通常与执行功能 (EF) 缺陷有关。一些 EF 组件如反应抑制已在 JME 中得到广泛评估,但很少有研究关注性状冲动或 GGE 亚型之间的比较。本研究的目的是比较 JME 中性状冲动性与其他 GGE 亚型的关联。方法 14~40岁GGE患者(n=137)分为JME患者(n=92)和其他GGE患者(n=45:8例儿童失神癫痫(CAE),22例青少年失神癫痫(JAE) ) 和 15 例仅伴有全身强直阵挛发作 (EGTCS) 的癫痫。研究参与者是通过布斯克鲁德县和邻近城市一般人口的医疗记录招募的,覆盖了 477,000 人,占挪威总人口的 9.1%。所有参与者都接受了包括 Barratt 冲动量表 (BIS) 在内的临床访谈,这是一种既定的特质冲动量表。我们使用协方差分析 (ANCOVA) 控制了 BIS 评分的其他潜在预测因素。结果 JME 和其他类型的 GGE 之间的 BIS 评分没有差异,但过去一年内肌阵挛性癫痫的存在,无论 GGE 亚型如何,都与显着增加的行为冲动独立相关。
更新日期:2020-11-01
down
wechat
bug