Anthracyclines (ANT), belong to a group of antineoplastic drugs, are commonly used as chemotherapeutic agents in the treatment of various cancers. During the past decade, the number of cancer patients receiving ANT–based chemotherapy drugs has significantly increased. Generally, ANT are very cytotoxic agents and are known to be accompanied by several unpleasant adverse effects. Therefore, the development of a reliable, accurate and sensitive analytical method is necessary and important to analyze ANT in human biomonitoring. The objective of this review is to provide a summary of various analytical methods (spectroscopic, liquid chromatographic and electroanalytical) that have been reported during the last four decades for the analysis of the five most commonly used ANT, daunorubicin (DNR), doxorubicin (DOX), epirubicin (EPI), idarubicin (IDA), valrubicin (VAL) and their metabolites, alone or in combination with other drugs, in various matrices such as biological matrices, environmental samples and pharmaceutical formulations.

蒽环类药物（ANT）属于抗肿瘤药，通常用作治疗各种癌症的化学治疗剂。在过去的十年中，接受基于ANT的化学治疗药物的癌症患者数量显着增加。通常，ANT是非常具有细胞毒性的药物，并且已知会伴随多种不良反应。因此，开发一种可靠，准确和灵敏的分析方法对于在人类生物监测中分析ANT是必要且重要的。这篇综述的目的是提供过去四十年中已报告的用于分析五种最常用的ANT，柔红霉素（DNR），阿霉素（DOX）的各种分析方法（光谱，液相色谱和电分析）的摘要。 ），表柔比星（EPI），依达比星（IDA），