Total syntheses of (S)- and (R)-nuciferine were accomplished through approach involving diastereoselective reaction between a chiral dihydroisoquinoline enamide and 2-(trimethylsilyl)phenyl trifluoromethanesulfonate promoted by CsF, affording a separable mixture of diastereoisomers, which provided (S)- and (R)-nuciferine via simple and efficient transformations.

中文翻译：

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使用苯并炔化学的立体选择性全合成（S）-和（R）-核苷

（S）-和（R）-核苷的总合成是通过涉及手性二氢异喹啉烯酰胺与CsF促进的2-（三甲基甲硅烷基）苯基三氟甲磺酸酯之间的非对映选择性反应的方法完成的，从而提供了可分离的非对映异构体混合物，从而提供了（S）-和（R）-核苷通过简单而有效的转化。