Abstract In recent years, saliva has been introduced as an alternate to conventional biofluid assays owing to both accessibility and reliability with regard to the assessment of different biomarkers. The capability of immediate online collection and analysis of salivary biomarkers offers myriad benefits for clinical applications, resulting in the demands for quantifying salivary biomarkers rapidly and reliably with the help of biosensing technology. Carbon–nanomaterial based biosensors provide potential instruments for a non-aggressive pain-free style of saliva-dependent recognition to diagnoses, monitor, and formulate a therapeutic modality and for managing patients. This review covers the importance of carbon nanomaterial in fabricating salivary-based detectors applied clinically for diagnostics and therapeutics. The utilization of carbon nanomaterials comprising carbon dots (CDs), carbon nanotubes (CNTs), graphene, graphene oxide (GO), reduced graphene oxide (rGO) and graphitic carbon nitride (g-C3N4) in salivary-based detection has been highlighted here with up-to-date instances. These sensing systems are capable of detecting a vast range of molecules with clinical relevance, including glucose, hormones, amino acids, viruses, bacteria, cancer antigens, cancer biomarkers, dopamine, sialic acid, uric acid, etc. which were discussed in this paper.

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用于基于唾液的生物传感器的碳纳米材料：综述

摘要 近年来，由于评估不同生物标志物的可及性和可靠性，唾液已被引入作为传统生物流体测定的替代方法。唾液生物标志物的即时在线收集和分析能力为临床应用提供了无数好处，从而需要借助生物传感技术快速可靠地量化唾液生物标志物。基于碳纳米材料的生物传感器为非攻击性无痛唾液依赖性识别提供了潜在的工具，用于诊断、监测和制定治疗方式以及管理患者。这篇综述涵盖了碳纳米材料在制造临床上用于诊断和治疗的基于唾液的检测器的重要性。包括碳点 (CD)、碳纳米管 (CNT)、石墨烯、氧化石墨烯 (GO)、还原氧化石墨烯 (rGO) 和石墨氮化碳 (g-C3N4) 在内的碳纳米材料在唾液检测中的应用得到了强调具有最新的实例。这些传感系统能够检测大量具有临床相关性的分子，包括葡萄糖、激素、氨基酸、病毒、细菌、癌抗原、癌症生物标志物、多巴胺、唾液酸、尿酸等。 .