This study investigated Lactobacillus plantarum KFY02 (KFY02) and its ability to enhance the antioxidant capacity of the body by converting geniposide to genipin, thereby decreasing the liver damage induced by CCl₄ in mice. The experimental results showed that geniposide is partially converted into genipin by KFY02. In liver-injured mice, KFY02 and geniposide could decrease the liver index, the AST, ALT, TG, and MDA serum levels, and the levels of cytokines IL-6, IL-12, TNF-α, and IFN-γ while up-regulating SOD and GSH-Px levels. KFY02 and geniposide increased the mRNA and protein expression of Mn-SOD, Cu/Zn-SOD, CAT, GSH-Px, and IκB-α and decreased the mRNA and protein expression of COX-2, iNOS, and NF-κB in the liver tissue of liver-injured mice. In summary, the conversion of geniposide to genipin by L. plantarum KFY02 can effectively enhance the body's antioxidant capacity to prevent CCl₄-induced liver damage in mice.

这项研究调查了植物乳杆菌KFY02（KFY02）及其通过将子苷转化为Genipin来增强机体抗氧化能力的能力，从而减少了CCl ₄诱导的肝损伤在小鼠中。实验结果表明gen子苷被KFY02部分转化为子苷。在肝损伤的小鼠中，KFY02和子苷可以降低肝脏指数，AST，ALT，TG和MDA血清水平，并在升高时降低细胞因子IL-6，IL-12，TNF-α和IFN-γ的水平。调节SOD和GSH-Px水平。KFY02和gen子苷增加了Mn-SOD，Cu / Zn-SOD，CAT，GSH-Px和IκB-α的mRNA和蛋白表达，降低了COX-2，iNOS和NF-κB的mRNA和蛋白表达。肝损伤小鼠的肝组织。综上所述，植物乳杆菌KFY02将side子苷转化为Genipin可以有效增强机体的抗氧化能力，从而防止CCl ₄诱导的小鼠肝损伤。