The foreign body response caused by implanted biomaterials hampers their close integration and thereby result in a failure of the implant or tissue-engineering scaffolds, which represent a huge challenge. Here, we prepare anisotropic micro−/nano-wrinkled surfaces on polydimethylsiloxane that mediates hepatic stellate cell (HSC) responses and hepatic fibrosis. It is found that LX-2 cell attachment and morphology are greatly dependent on the wrinkle sizes. Further, the gene and protein expressions of hepatic fibrosis markers (i.e., α-SMA and Col-I) on wrinkled PDMS surface were reduced compared to the control group. Moreover, anisotropic wrinkled surfaces could accelerate the degradation of collagen by increasing the expression of matrix metalloproteinases (MMPs) and decreasing the formation of MMPs inhibitors. This study provides an effective strategy for reducing the fibrotic response and thus improving the efficacy and safety of novel tissue-engineering scaffolds and implants.

由植入的生物材料引起的异物反应阻碍了它们的紧密整合，从而导致植入物或组织工程支架的失效，这是一个巨大的挑战。在这里，我们在聚二甲基硅氧烷上制备了各向异性的微/纳米皱纹表面，该表面介导了肝星状细胞（HSC）反应和肝纤维化。发现LX-2细胞的附着和形态在很大程度上取决于皱纹的大小。此外，与对照组相比，皱纹PDMS表面的肝纤维化标记物（即α-SMA和Col-I）的基因和蛋白质表达降低。此外，各向异性的起皱表面可通过增加基质金属蛋白酶（MMPs）的表达并减少MMPs抑制剂的形成来加速胶原蛋白的降解。