For the controlled drug release delivery system, gold nanomaterials have received considerable attention for their photothermal effect in medical applications. The exploration of green and facile methods for constructing efficient gold based nanomaterials to control drug release is greatly needed. Hence, we aim to prepare procyanidins (PCs) reduced gold nanoparticles (AuNPs) coated doxorubicin (DOX) liposomes (DOX–PCs–Lips@AuNPs), of which PCs were modified on phosphatidylcholine and acted as both reductant and stabilizer during the synthesis of AuNPs. As a result, AuNPs were successfully synthesized by PCs, so as to avoid the use of traditional reductants. The as prepared DOX–PCs–Lips@AuNPs were proved to have spherical shape, good photothermal property and controlled drug release behavior after 808 nm laser irradiation. As a green and facile synthesized nanomaterial, DOX–PCs–Lips@AuNPs would consolidate the medical application of AuNPs.

对于药物释放控制系统，金纳米材料因其在医疗应用中的光热效应而备受关注。迫切需要探索绿色和简便的方法来构建有效的金基纳米材料，以控制药物的释放。因此，我们的目的是制备原花青素（PCs）还原的金纳米颗粒（AuNPs）包被的阿霉素（DOX）脂质体（DOX-PCs-Lips @ AuNPs），其中PCs在磷脂酰胆碱上修饰并在合成过程中既起还原剂作用，又起稳定剂作用。 AuNPs。结果，PC成功地合成了AuNP，从而避免了使用传统的还原剂。所制备的DOX–PCs–Lips @ AuNPs在808 nm激光辐照后具有球形，良好的光热性能和受控的药物释放行为。