Abstract

Broad application of mass spectrometry in clinical practice was only possible with the development of the physicochemical fundamentals of the method. New ionization techniques and ion detection systems have not only enhance the variety of biomolecules in diagnostics, but also provided an opportunity to apply direct mass spectrometry methods to guide surgical interventions. Here we present a brief review of the latest achievements in mass spectrometry applications in oncological surgery and neurosurgery in particular. We describe our recent advance in this area and demonstrate that the combination of different mass spectrometric techniques improves the overall comprehensiveness of the analysis.

中文翻译：

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新型肿瘤实用工具，可协助肿瘤外科手术

摘要

质谱法在临床实践中的广泛应用只有通过该方法的物理化学基础的发展才能实现。新的电离技术和离子检测系统不仅增加了诊断中生物分子的种类，而且为应用直接质谱方法指导手术干预提供了机会。在这里，我们简要介绍一下质谱在肿瘤外科尤其是神经外科中的最新应用。我们描述了我们在该领域的最新进展，并证明了不同质谱技术的结合可以提高分析的整体综合性。