Abstract

We proposed a method for the selective and highly sensitive amperometric determination of dopamine and adrenaline in the presence of ascorbic and uric acids in a flow-injection system. Screen-printed electrodes modified with palladium nanoparticles, exhibiting catalytic activity in the electrooxidation of catecholamines, were used as a detector. The difference between the oxidation peak potentials of these compounds is 200 mV. A linear bilogarithmic dependence of the analytical signal on the concentration of dopamine and adrenaline is observed in the ranges from 5 × 10^–12 to 5 × 10^–8 M and from 1 × 10^–9 to 1 × 10^–5 M, respectively. For simultaneous two-component analysis, screen-printed electrodes with two working electrodes were used, that is, dual screen-printed electrodes modified with palladium nanoparticles, which enable two substances to be determined simultaneously at two different potentials. The proposed method for the joint flow-injection amperometric determination of dopamine and adrenaline using a modified dual screen-printed electrode was tested in the analysis of urine.

中文翻译：

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钯纳米粒子双丝网印刷电极用于流动注射安培法测定多巴胺和肾上腺素

摘要

我们提出了一种在流动注射系统中存在抗坏血酸和尿酸的情况下，对多巴胺和肾上腺素进行选择性和高灵敏度安培测定的方法。在儿茶酚胺的电氧化中表现出催化活性的用钯纳米颗粒修饰的丝网印刷电极被用作检测器。这些化合物的氧化峰电位之间的差为200 mV。在5×10 ^–12至5×10 ^–8 M以及1×10 ^–9至1×10 ^–5的范围内观察到分析信号对多巴胺和肾上腺素浓度的线性对数依赖性。M分别。为了同时进行两组分分析，使用了带有两个工作电极的丝网印刷电极，即用钯纳米粒子修饰的双丝网印刷电极，这使得能够同时在两种不同电势下确定两种物质。在尿液分析中测试了所提出的使用改进的双丝网印刷电极联合流动注射安培法测定多巴胺和肾上腺素的方法。