Abstract

Hybrid materials based on perfluorinated sulfonic acid Nafion-type membranes and poly-3,4-ethylenedioxythiophene (PEDOT) with a gradient distribution of the latter along the film length were synthesized by in situ oxidative polymerization. The initial monomer concentration (0.01 and 0.002 M) and the concentration ratio of the monomer to the oxidant (1/1.25 and 1/2.5) were varied. We studied the effect of the equilibrium and transport properties of the obtained materials on the characteristics of cross-sensitive DP-sensors (analytical signal is the Donnan potential) in aqueous solutions of procaine, lidocaine, and bupivacaine hydrochlorides, including those containing sodium chloride, in a concentration range from 1.0 × 10^–4 to 1.0 × 10^–2 M and pH from 2 to 6. The relative error in determining the active substance in the Novokain preparation using a DP-sensor based on the Nafion/PEDOT membrane (0.002 M, 1/2.5) was 0.4%. An array of DP-sensors based on Nafion and Nafion/PEDOT (0.002 M, 1/1.25) membranes was used to determine bupivacaine hydrochloride and sodium chloride in the Markain® Spinal preparation with an error of 11 and 6%, respectively.

中文翻译：

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基于PEDOT修饰的Nafion膜的电位传感器，用于测定水溶液和药物中的普鲁卡因，利多卡因和布比卡因

摘要

通过原位氧化聚合反应，合成了基于全氟化磺酸Nafion型膜和聚-3,4-乙撑二氧噻吩（PEDOT）的杂化材料，后者沿膜的长度方向呈梯度分布。改变初始单体浓度（0.01和0.002M）以及单体与氧化剂的浓度比（1 / 1.25和1 / 2.5）。我们研究了所获得材料的平衡和传输特性对普鲁卡因，利多卡因和布比卡因盐酸盐水溶液（包括含氯化钠的溶液）中的交叉敏感DP传感器（分析信号为Donnan势）的特性的影响，浓度范围从1.0×10 ^–4到1.0×10 ^–2M和pH值为2至6。使用基于Nafion / PEDOT膜的DP传感器（0.002 M，1 / 2.5）确定Novokain制剂中活性物质的相对误差为0.4％。基于Nafion和Nafion / PEDOT（0.002 M，1 / 1.25）膜的一系列DP传感器用于测定Markain®脊髓制剂中的盐酸布比卡因和氯化钠，其误差分别为11和6％。