The mucous layer on the surface of human digestive tract is a dynamically balanced protective system, mainly containing mucin, enzymes, bicarbonate, epidermal growth factor and other protective factors. It has been found that mucins can protect epithelial cells from infection, dehydration, and physical, mechanical or chemical damage. There are a variety of disturbances that affect or destroy the function of the mucous layer, including mucus dysfunction and diseases of digestive tract. In this paper, the mechanical function of mucin on the surface of esophagus was studied using the UMT Tribometer with the porcine esophagus as the experiment sample. Trypsin was used to control the mucin content on the surface of esophagus. Results showed that the trypsin can affect the function of the mucin on the surface of esophagus. The friction coefficient and the relevant energy dissipation of trypsin-treated and non-trypsin-treated samples were significantly different. Due to the reduction of mucin on the esophageal surface by trypsin treatment, the friction coefficient and energy dissipation of the esophageal surface were significantly higher than that of the samples without trypsin treatment. During the friction test, the esophagus surface was severely damaged at both macro and micro scales after trypsin treatment, which indicated that the mucin can play a lubrication role at the gastroscope device-esophagus interface. The results can provide reference for clinical endoscopic examination and medical advice for clinical practice.

中文翻译：

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粘蛋白在胃镜设备-食管界面的润滑功能

人消化道表面的粘液层是动态平衡的保护系统，主要包含粘蛋白，酶，碳酸氢盐，表皮生长因子和其他保护因子。已经发现粘蛋白可以保护上皮细胞免受感染，脱水以及物理，机械或化学损伤。有多种影响或破坏粘液层功能的障碍，包括粘液功能障碍和消化道疾病。本文采用UMT Tribometer，以猪食管为实验样品，研究了粘蛋白在食管表面的力学功能。胰蛋白酶用于控制食道表面粘蛋白的含量。结果表明，胰蛋白酶可以影响粘蛋白在食道表面的功能。胰蛋白酶处理和非胰蛋白酶处理的样品的摩擦系数和相关的能量耗散有显着差异。由于通过胰蛋白酶处理减少了粘膜在食管表面上的粘蛋白，食管表面的摩擦系数和能量耗散明显高于未经胰蛋白酶处理的样品。在摩擦试验中，胰蛋白酶处理后，食管表面在宏观和微观上都受到了严重破坏，这表明粘蛋白可以在胃镜装置-食道界面上起润滑作用。研究结果可为临床内镜检查及临床实践提供医学参考。由于通过胰蛋白酶处理减少了粘膜在食管表面上的粘蛋白，食管表面的摩擦系数和能量耗散明显高于未经胰蛋白酶处理的样品。在摩擦试验中，胰蛋白酶处理后，食管表面在宏观和微观上都受到了严重破坏，这表明粘蛋白可以在胃镜装置-食道界面上起润滑作用。研究结果可为临床内镜检查及临床实践提供医学参考。由于通过胰蛋白酶处理减少了粘膜在食管表面上的粘蛋白，食管表面的摩擦系数和能量耗散明显高于未经胰蛋白酶处理的样品。在摩擦试验中，胰蛋白酶处理后，食管表面在宏观和微观上都受到了严重破坏，这表明粘蛋白可以在胃镜装置-食道界面上起润滑作用。研究结果可为临床内镜检查和临床实践提供医学参考。胰蛋白酶处理后，食管表面在宏观和微观上均受到严重破坏，这表明粘蛋白可以在胃镜装置-食道界面上起润滑作用。研究结果可为临床内镜检查及临床实践提供医学参考。胰蛋白酶处理后，食管表面在宏观和微观上均受到严重破坏，这表明粘蛋白可以在胃镜装置-食道界面上起润滑作用。研究结果可为临床内镜检查及临床实践提供医学参考。