Background 3,4-Methylenedioxymethamphetamine intoxication can result in potentially lethal multi-organ failure, for which the current treatment is largely supportive. Recently, a report of the use of the CytoSorb device as a part of the successful treatment of a patient with 3,4-methylenedioxymethamphetamine intoxication and multi-organ failure has been described. Main body While 3,4-methylenedioxymethamphetamine was very effectively removed by CytoSorb in vitro, the degree of removal in the clinical setting described may have been minimal. Indeed, the therapy was started relatively late in this case, and, as the therapy is concentration dependent, the removal of 3,4-methylenedioxymethamphetamine is likely to have been limited. On the other hand, in this case, CytoSorb hemoadsorption was very effective to treat rhabdomyolysis and hyperinflammation. Conclusion The in vitro experimentation demonstrates that 3,4-methylenedioxymethamphetamine is effectively removed by CytoSorb. However, it is debatable whether the case report confirms the possibility of in vivo removal of 3,4-methylenedioxymethamphetamine by CytoSorb. Nevertheless, the potential of the CytoSorb device to contribute to the treatment of many critically ill patients has yet to be fully explored, and further studies are warranted.

中文翻译：

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CytoSorb 在体外去除 MDMA，但它是一种有效的体内疗法吗？

背景 3,4-亚甲二氧基甲基苯丙胺中毒可导致潜在的致命性多器官衰竭，目前的治疗在很大程度上是支持性的。最近，有报道称使用 CytoSorb 装置作为成功治疗 3,4-亚甲二氧基甲基苯丙胺中毒和多器官衰竭患者的一部分。主体 虽然 CytoSorb 在体外可以非常有效地去除 3,4-亚甲基二氧基甲基苯丙胺，但在所述临床环境中的去除程度可能很小。事实上，在这种情况下，治疗开始的时间相对较晚，并且由于治疗依赖于浓度，3,4-亚甲二氧基甲基苯丙胺的去除可能受到限制。另一方面，在这种情况下，CytoSorb 血液吸附对治疗横纹肌溶解症和过度炎症非常有效。结论体外实验表明CytoSorb能有效去除3,4-亚甲二氧基甲基苯丙胺。然而，病例报告是否证实了 CytoSorb 体内去除 3,4-亚甲基二氧基甲基苯丙胺的可能性仍有待商榷。尽管如此，CytoSorb 装置在治疗许多重症患者方面的潜力尚未得到充分探索，还需要进一步的研究。