A novel antimicrobial dental composite resin has been developed and evaluated. Alumina filler particles were covalently coated with an antibacterial resin and blended into a composite resin formulation. Surface hardness and bacterial viability were used to evaluate the modified composite resin. Results showed that almost all the modified composite resins exhibited higher antibacterial activity along with improved surface hardness, as compared to unmodified one. Effects of antibacterial moiety content on the modified fillers, modified alumina particle size and loading, and total filler content were investigated. It was found that increasing antibacterial moiety content, particle size and loading of the modified filler, and total filler content generally increased surface hardness. Increasing antibacterial moiety, filler loading and total filler content increased antibacterial activity. On the other hand, increasing particle size showed a negative impact on antibacterial activity. The leaching tests indicate that the modified experimental composite resin showed no leachable antibacterial component to bacteria and 3T3 mouse fibroblasts.

中文翻译：

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一种提高抗菌功能和硬度的牙科填充复合树脂修复剂

一种新型抗菌牙科复合树脂已被开发和评估。氧化铝填料颗粒用抗菌树脂共价涂覆并混合到复合树脂配方中。表面硬度和细菌活力用于评估改性复合树脂。结果表明，与未改性的复合树脂相比，几乎所有改性的复合树脂都表现出更高的抗菌活性和更高的表面硬度。研究了抗菌部分含量对改性填料、改性氧化铝粒径和负载量以及总填料含量的影响。发现增加抗菌部分含量、改性填料的粒径和负载量以及总填料含量通常会增加表面硬度。增加抗菌成分，填料负载和总填料含量增加了抗菌活性。另一方面，增加粒径对抗菌活性有负面影响。浸出试验表明，改性实验复合树脂对细菌和3T3小鼠成纤维细胞没有可浸出的抗菌成分。