Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase.,Journal of Antimicrobial Chemotherapy

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Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase.
Journal of Antimicrobial Chemotherapy ( IF 5.2 ) Pub Date : 2020-07-30 , DOI: 10.1093/jac/dkaa286
Sara R Henderson _{1,

2} , Clare E M Stevenson ₁ , Brandon Malone _{1,

3} , Yelyzaveta Zholnerovych ₁ , Lesley A Mitchenall ₁ , Mark Pichowicz _{4,

5} , David H McGarry _{4,

6} , Ian R Cooper _{4,

7} , Cedric Charrier _{4,

8} , Anne-Marie Salisbury _{4,

9} , David M Lawson ₁ , Anthony Maxwell ₁

Affiliation

To evaluate the efficacy of two novel compounds against mycobacteria and determine the molecular basis of their action on DNA gyrase using structural and mechanistic approaches.

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