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Preparation, characterization, and in vitro drug release behavior of thiolated alginate nanoparticles loaded budesonide as a potential drug delivery system toward inflammatory bowel diseases.
Journal of Biomaterials Science, Polymer Edition ( IF 3.6 ) Pub Date : 2020-09-03 , DOI: 10.1080/09205063.2020.1803034
Muhammad Arif 1 , Zhe Chi 1 , Yong-Jun Liu 2 , Chen-Guang Liu 1
Affiliation  

Abstract

For site-specific drug delivery in inflammatory bowel disease, reducible sodium alginate nanoparticles cross-linked with disulfide linkage were developed. Nanoparticles were synthesized in deionized water through self-assembly of amphiphilic thiolated sodium alginate Alg-Cys and subsequently produced cross-linking of disulfide bonds. TEM image showed a spherical core-shell configuration with a size of about 430 nm for the nanoparticles. Dynamic light scattering (DLS) showed high stability, narrow size distribution, and pH-dependent swelling transition for the nanoparticles. Cytotoxicity study showed that there was no evident cell inhibition among the nanoparticles. Also, the size of the nanoparticles increased in 10 mM glutathione (GSH) solution due to the cleavage of disulfides within their network structures. Compared to that in GSH-free buffer, there was a remarkable increase in drug release in pH 7.4 buffer with GSH from drug-loaded nanoparticles, indicating that the nanoparticles could be used for colon-specific drug delivery.



中文翻译:

负载布地奈德的硫醇化海藻酸盐纳米颗粒的制备、表征和体外药物释放行为,作为治疗炎症性肠病的潜在药物递送系统。

摘要

对于炎症性肠病中的位点特异性药物递送,开发了与二硫键交联的可还原海藻酸钠纳米颗粒。通过两亲性硫醇化海藻酸钠 Alg-Cys 的自组装在去离子水中合成纳米颗粒,随后产生二硫键的交联。TEM 图像显示了球形核壳结构,纳米颗粒的尺寸约为 430 nm。动态光散射 (DLS) 显示出纳米颗粒的高稳定性、窄尺寸分布和 pH 依赖性溶胀转变。细胞毒性研究表明纳米颗粒之间没有明显的细胞抑制作用。此外,纳米颗粒在 10 mM 谷胱甘肽 (GSH) 溶液中的尺寸由于其网络结构内二硫化物的裂解而增加。与不含 GSH 的缓冲液相比,

更新日期:2020-09-03
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