Recent research has demonstrated frontal cortical involvement to co-occur with visual re-organization, suggestive of top-down modulation of cross-modal mechanisms. However, it is unclear whether top-down modulation of visual re-organization takes place in mild hearing loss, or is dependent upon greater degrees of hearing loss severity. Thus, the purpose of this study was to determine if frontal top-down modulation of visual cross-modal re-organization increased across hearing loss severity. We recorded visual evoked potentials (VEPs) in response to apparent motion stimuli in 17 adults with mild-moderate hearing loss using 128-channel high-density electroencephalography (EEG). Current density reconstructions (CDRs) were generated using sLORETA to visualize VEP generators in both groups. VEP latency and amplitude in frontal regions of interest (ROIs) were compared between groups and correlated with auditory behavioral measures. Activation of frontal networks in response to visual stimulation increased across mild to moderate hearing loss, with simultaneous activation of the temporal cortex. In addition, group differences in VEP latency and amplitude correlated with auditory behavioral measures. Overall, these findings support the hypothesis that frontal top-down modulation of visual cross-modal re-organization is dependent upon hearing loss severity.

中文翻译：

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听力丧失的成年人的颞部视觉跨模态重组的额叶皮质调制。

最近的研究表明额叶皮层参与与视觉重组同时发生，提示自上而下调节交叉模式机制。然而，尚不清楚自上而下的视觉重组调节是在轻度听力损失中发生还是取决于更大程度的听力损失严重程度。因此，本研究的目的是确定跨听力损失严重程度的正面，自上而下的视觉交叉模态重组的调节。我们记录了使用128通道高密度脑电图（EEG）对17名轻度中度听力下降的成年人的视运动诱发的视觉诱发电位（VEP）。使用sLORETA生成电流密度重建（CDR），以可视化两组中的VEP发生器。比较各组之间额叶感兴趣区域（ROI）的VEP潜伏期和幅度，并将其与听觉行为指标相关联。在轻度至中度听力损失期间，额叶网络的激活在视觉刺激的同时增加，同时颞皮质也激活。另外，VEP潜伏期和振幅的组差异与听觉行为测量相关。总体而言，这些发现支持这样的假说：视觉交叉模态重组的正面自上而下的调制取决于听力损失的严重程度。VEP潜伏期和振幅的群体差异与听觉行为指标有关。总体而言，这些发现支持这样的假说：视觉交叉模态重组的正面自上而下的调制取决于听力损失的严重程度。VEP潜伏期和振幅的群体差异与听觉行为指标有关。总体而言，这些发现支持这样的假说，即视觉交叉模态重组的正面自上而下的调制取决于听力损失的严重程度。