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New Alkenylresorcinols with Cytotoxic and Antimicrobial Activities from the Leaves of Embelia schimperi
Planta Medica ( IF 2.7 ) Pub Date : 2020-07-29 , DOI: 10.1055/a-1209-3501
Tatiana Arlette M Togue 1 , Blanche Laure Ndontsa 1 , Gabin Thierry M Bitchagno 1, 2 , Anja Schüffler 3 , Till Opatz 2 , Pierre Tane 1 , Mathieu Tene 1
Affiliation  

A phytochemical study of the methanol extract of the leaves of Embelia schimperi resulted in the isolation of three new alkenylresorcinols, 1: - 3: , together with the known analogs 4: - 7: . Their structures were established by a combination of spectroscopic techniques. Compounds 1: - 7: exhibited moderate cytotoxic activity against human cervical cancer cells HeLa-S3 and more pronounced antimicrobial properties towards bacteria and filamentous fungi. The present study falls into an ongoing research project on the characterization of bioactive phenolic lipids from plants of the family Primulaceae.

中文翻译:

来自 Embelia schimperi 叶的具有细胞毒性和抗菌活性的新烯基间苯二酚

对 Embelia schimperi 叶子甲醇提取物的植物化学研究导致分离出三种新的链烯基间苯二酚 1: - 3: 以及已知的类似物 4: - 7: 。它们的结构是通过光谱技术的组合建立的。化合物1:-7:对人宫颈癌细胞HeLa-S3表现出中等的细胞毒活性,对细菌和丝状真菌具有更显着的抗菌特性。本研究属于一项正在进行的研究项目,该研究项目对来自报春科植物的生物活性酚类脂进行表征。
更新日期:2020-07-29
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