The experiment focused the most effective dose out of 2.5, 5, and 10 mg/100 g body weight/day for 4 weeks of n‐butanol fraction from the pretested promising hydro‐methanol extract of Musa balbisiana flower to manage the streptozotocin‐induced diabetes in rat and to minimize the bioburden of the body by excluding the inactive components from the said extract. Fraction treatment exhibited an outstanding recovery in fasting blood glucose, glycated hemoglobin, serum insulin levels, carbohydrate metabolic, antioxidant enzymes activities, expression of their marker genes, and apoptotic gene in diabetic rat. Flow‐cytometric study of pancreatic β‐cell population was significantly recovered in fraction‐treated groups which was also supported by histological study. The moderate dose, that is, 5 mg dose showed maximum efficacy in respect to other doses. The high dose, that is, 10 mg dose is not significantly effective than 5 mg dose may be due to the desensitization of the target organ's orphan receptor(s).

中文翻译：

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链脲佐菌素诱导的糖尿病大鼠模型中血糖和氧化应激传感器的校正：香蕉花（Musa balbisiana）的水-甲醇提取物的正丁醇溶剂组分的剂量依赖性研究的影响。

该实验将来自2.5天，5天和10毫克/ 100克体重/天的最有效剂量集中于来自预先测试的有前景的芭蕉的氢甲醇提取物的4周正丁醇馏分可以通过排除上述提取物中的非活性成分来控制大鼠链脲佐菌素诱导的糖尿病并最大程度地降低人体的生物负荷。分部治疗在糖尿病大鼠中表现出空腹血糖，糖化血红蛋白，血清胰岛素水平，碳水化合物代谢，抗氧化酶活性，其标志物基因的表达和凋亡基因的显着恢复。流式细胞术研究胰腺β细胞群体在部分处理组中显着恢复，这也得到了组织学研究的支持。中等剂量，即5mg剂量显示出相对于其他剂量的最大功效。高剂量，即10 mg剂量比5 mg剂量效果不明显，可能是由于靶器官的孤儿受体脱敏所致。