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Adjusting for allometric scaling in ABIDE I challenges subcortical volume differences in autism spectrum disorder.
Human Brain Mapping ( IF 4.8 ) Pub Date : 2020-07-30 , DOI: 10.1002/hbm.25145
Camille Michèle Williams 1 , Hugo Peyre 1, 2, 3 , Roberto Toro 4, 5 , Anita Beggiato 3, 5 , Franck Ramus 1
Affiliation  

Inconsistencies across studies investigating subcortical correlates of autism spectrum disorder (ASD) may stem from small sample size, sample heterogeneity, and omitting or linearly adjusting for total brain volume (TBV). To properly adjust for TBV, brain allometry—the nonlinear scaling relationship between regional volumes and TBV—was considered when examining subcortical volumetric differences between typically developing (TD) and ASD individuals. Autism Brain Imaging Data Exchange I (ABIDE I; N = 654) data was analyzed with two methodological approaches: univariate linear mixed effects models and multivariate multiple group confirmatory factor analyses. Analyses were conducted on the entire sample and in subsamples based on age, sex, and full scale intelligence quotient (FSIQ). A similar ABIDE I study was replicated and the impact of different TBV adjustments on neuroanatomical group differences was investigated. No robust subcortical allometric or volumetric group differences were observed in the entire sample across methods. Exploratory analyses suggested that allometric scaling and volume group differences may exist in certain subgroups defined by age, sex, and/or FSIQ. The type of TBV adjustment influenced some reported volumetric and scaling group differences. This study supports the absence of robust volumetric differences between ASD and TD individuals in the investigated volumes when adjusting for brain allometry, expands the literature by finding no group difference in allometric scaling, and further suggests that differing TBV adjustments contribute to the variability of reported neuroanatomical differences in ASD.

中文翻译:

在 ABIDE I 中调整异速生长对自闭症谱系障碍的皮层下体积差异提出挑战。

调查自闭症谱系障碍 (ASD) 皮层下相关性的研究之间的不一致可能源于样本量小、样本异质性以及忽略或线性调整总脑容量 (TBV)。为了正确调整 TBV,在检查典型发育 (TD) 和 ASD 个体之间的皮层下体积差异时,考虑了大脑异速生长——区域体积和 TBV 之间的非线性比例关系。自闭症脑成像数据交换 I (ABIDE I; N= 654) 使用两种方法分析数据:单变量线性混合效应模型和多变量多组验证性因素分析。对整个样本和基于年龄、性别和全面智商 (FSIQ) 的子样本进行了分析。重复了一项类似的 ABIDE I 研究,并研究了不同 TBV 调整对神经解剖组差异的影响。在跨方法的整个样本中没有观察到强大的皮层下异速生长或体积组差异。探索性分析表明,在由年龄、性别和/或 FSIQ 定义的某些亚组中可能存在异速生长缩放和体积组差异。TBV 调整的类型影响了一些报告的体积和缩放组差异。
更新日期:2020-07-30
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