Polycaprolactone nanoparticles (PCL NPs) were produced by a liquid nonsolvent nanoprecipitation process in a flow‐focusing microfluidic device and optimized in terms of particle size, polydispersity index (PDI), and zeta potential ζ. The effects of flow rate ratio (FRR), total flow rate (TFR), the organic solvents tetrahydrofuran and dimethylformamide (DMF), the surfactants polyvinyl alcohol and Tween 80, and polymer molecular weight on the size, PDI, and ζ of PCL NPs were investigated. A stability study was performed to compare the effect of the surfactants on the characteristics of PCL NPs over 7 d. The smallest particles are produced at the highest FRR, TFR, and polymer molecular weight and lowest polymer concentration in DMF. The presence of both surfactants results in smaller NPs.

中文翻译：

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流动聚焦微流辅助纳米沉淀法合成聚己内酯纳米粒子

聚己内酯纳米颗粒（PCL NPs）是通过液体非溶剂纳米沉淀工艺在聚流微流体装置中生产的，并在粒度，多分散指数（PDI）和Zeta电位ζ方面进行了优化。流速比（FRR），总流速（TFR），有机溶剂四氢呋喃和二甲基甲酰胺（DMF），表面活性剂聚乙烯醇和吐温80以及聚合物分子量对尺寸，PDI和ζ的影响对PCL NP的数量进行了研究。进行了稳定性研究，以比较表面活性剂在7天内对PCL NPs特性的影响。以最高的FRR，TFR和聚合物分子量以及最低的DMF聚合物浓度生产最小的颗粒。两种表面活性剂的存在都会导致较小的NP。